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Pharmacology > Bioavailability > Flashcards

Bioavailability Flashcards

1
Q

Calculate Bioavailability of drugs

A

F = AUC [Route ex Oral] / AUC IV

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2
Q

Loading Dose

Maintenance Dose

A

Loading Dose: Given quickly to achieve volume of distribution/desired plasma level

Maintenance: Given to maintain plasma concentration writhing therapeutic levels over longer period of time

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3
Q

Loading dose calc

A

Ld = [Target plasma concentration * Volume distribution] / Bioavailability

*Ladies Come to Vancouver for Flowers

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4
Q

Maintenance dose Calc

A

MD = Dosing Rate * Dosing Interval

Dosing Rate = [Cp * Cl] / F

SO MD = Cp * Cl * Dose interval / F

*Maintenance Comes to DO the Cleaning of the Floor

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5
Q

Change of Dose in Liver/Renal disease

A

Maintenance Dose is Decreased

*Ld is UNCHANGED

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6
Q

Half lives to reach steady state

A

Usually 4-5 Half lives

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Pharmacology (18 decks)

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