Antiparistics Flashcards
Melarsoprol
- Binds to inhibit parasitic enzymes of sulfhydryl group
- Later staves of CNS involvement
Leishmaniasis
- Sodium stibogluconate -> Mech unknown
- Miltefosine -> Bind to parasitic DNA/inhibits CytC
Giardiasis
Metronidazole: Binds flaggella
Tinidazole: Disrupts DNA tertiary structure + NA synthesis
Quinacrine: Binds membranephosphlipis * Crosses Placenta
Nitazoxanide: Synthetic antiprotozoal
Trichomoniasis
Metronidazole
Tinidazole
**These drugs also treat Anaeroic bacterial infections
Luminal Amebicides
Iodoquinol
Paromomycin
Tinidazole/metronidazole
Paromomycin
- Intestinal amoebas
*** First Line for Amebiasis + Giardiasis in Pregnancy
Systemic Amebicides
Emetine + Dehydroemetine
*Contra in pregnancy and can cause Cardiotoxicity
Toxoplasmosis
Pyrimethamine + Sulfonamides
Atovaquone
Pneumocystosis
- TMP-SMZ
- Pentamidine
- Atovaquone
- Dapsone
- Eflornithine (IV)
- PRimaquine + Clindamycin
Antimalarial
Erythrocyte:
- Proguanil
- Pyrimethamine
Exoerythrocytic:
- Prophylactic: Proguanil + Pyrimethamine
- Primaquine
- Chloroquine + Quinine
Other:
- Mefloquine -> Resistant to Chloroquine
- Tafennoquine -> Single dose radical cure
- Malarone: Atovaquone + Proguanil
- CoArtem: Artemther + Lumefantrine -> Chinese Herb + LA Antimalarial
Common Antiprotozoal Adverse affects
- Embrytoxic
- GI disturbance
- Nausea
- Anorexia
- Voiting
- Dizziness
- Tinnitus
- Fatigue
Nematodes
- Mebendazole + Albendazole
- Pyrantel Pamoate
- Ivermectin
Wucheria Bancrofti
- Tissue Nematode —> Filariasis (tropical eosinophilia) + Elephantiasis; Hydrocele Testicles
- Treat: Diethylcarbamzine, Ivermectin, Albendazole
Niclosamide
- Used for Cestodes (Taenia)
- Use with Laxative for Ova
Praziquantel
- Trematodes (flukes) + Cestodes
- Schistosoma + Taenia
