ANS Pharm

Question 1

What are the NTs and receptors of the PANS?

Answer 1

PreG -> ACh -> Nicotinic -> PostG -> NE -> Muscarinic -> Effector

Question 2

NTs and receptors for SANS

Answer 2

PreG -> ACh -> Nicotinic -> PostG -> NE -> Effector

Question 3

Cholinergic neurons

Answer 3

PreG of ANS

Motor Neurons

PostG of PANS

Question 4

Exceptions of the ANS

Answer 4

Sweat Glands: Release ACh; but anatomically Sympathetic

Chromaffin Cells of Adrenal medulla: Nicotinic receptor which receive ACh, but Cells make Epinephrine

Dopaminergic Neurons: Can’t make NE, due to lack of enzyme

Question 5

Hemicholiniums

Answer 5

Block ACh uptake by blocking Na/Choline Symporter

Question 6

Vesamicol

Answer 6

Blocks ACh/H+ Antiporter VAT which prevents vesicle filling of ACh

Question 7

Botulinum Toxin

Answer 7

Prevents exocytosis of vesicles filled with ACh by binding and preventing SNARE- VAMP complexes

Question 8

Muscarinic Receptors

Answer 8

M1: Gq; CNS; Autonomuc Ganglia
M2: Gi; PNS; HEART
M3: Gq: PNS; Smooth muscle, glands, endothelium
M4: Gi: CNS
M5: Gq; CNS

Question 9

Nicotinic Receptor

Answer 9

N2(N) - Autonomic ganglia; Adrenal medulla; CNA

N1 (M) - NMJ

Both use Na/K Channels

Question 10

Rocuronium

Varenicline

Mecamylamine

Answer 10

Rocuroneum: SKM relaxant block of NM/N1

Varencline: Agonist of N/N or N2

Mexamylamine: Blocks NN / N2 at autonomic ganglia ONLY

Question 11

Metyrosine

Answer 11

Inhibits Tyrosine Hydroxylase (Competitive inibitor) -> Less NE

Question 12

Reserpine

Answer 12

Inhibits Enzyme which uptakes dopamine into vesicle to be converted into NE (VMAT antiporter)

Question 13

NE + Cocaine, Tricyclics, SSRIs

Answer 13

These drugs Inhibits NET which recycles NE.

Question 14

Droxidopa

Answer 14

Prodrug of NE given to treat symptomatic neurogenic orthostatic hypotension and those w/ B-hydroxylase deficiency

***Supine Hypertension

Question 15

Tyramine + Amphetamine

Answer 15

Sympathomimetics which Use NET to enter SANS terminal and VMAT to enter storage vesical and displace NE

NE is released into axoplasm through NET REVERSE MODE

Question 16

MAOI + Tryamine and NE

Answer 16

Increases NE levels

Tyramine —> Octopamine —> Lowered BP

Question 17

Differentiate binding of EP vs NE

Answer 17

NE binds B1&raquo_space;»»»>B2

EP binds B1 = B2

Both bind a1 = a2

Question 18

Alpha 1 receptors

Answer 18

Gq

Smooth muscle, Liver, GU tract

Question 19

Alpha 2

Answer 19

Gi

Platelets, Nerve terminals, vascular smooth muscle, Pancreatic B-Cells

Question 20

Beta 1

Answer 20

Gs

Heart+ Kidney

Question 21

Beta 2

Answer 21

Gs

Smooth muscle, Liver, SKM

Question 22

Beta 3

Answer 22

Gs

Adipose