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Antimicrobials > Quinolones > Flashcards

Quinolones Flashcards

1
Q

Origine

A

Acide nalidixique

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2
Q

Exemple

A 
Norfloxacine
Ofloxacine
Ciprofloxacin
Pefloxacine
Lomefloxacin
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3
Q

MoA

A

Empeche la replication de l’ADN et ciblant l’ADN gyrase et la topoisomerase II et IV

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4
Q

Indications ciprofloxacin

A 
\+ sur les gram -
   Uretrite gonococcique chez l'homme
   Infections urinaire basse et haute
   Infection intestinal
   Infection osteoarticulaire 
   Sinusites chronique 
Maladie du charbon
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5
Q

Indications levofloxacine

A 
Sinusite aiguës 
Pneumonies communautaires
Prostatites
Pyelonephrite aiguës 
Infection biliaires 
Infection intestinal
Maladie du charbon
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6
Q

Spectre d’activité

A

Levofloxacine: gram + en anaerobie
Ciprofloxacin: gram-

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7
Q

Contre indications

A

Enfant ou adolescent en croissance
Femme enceinte ou allaitante
Epilepsie
Deficit en G6PD
Insuffisance cardiaque hepatique ou renale grave
Athlete en periode d’entrainement ou de competition

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Antimicrobials (24 decks)

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