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Antimicrobials > Mecanismes D'action De Antibacteriens > Flashcards

Mecanismes D'action De Antibacteriens Flashcards

1
Q

Inhibiteurs de la synthese de la paroi bacterienne

A 
B-lactames
Bacitracine 
D-cycloserine
Fosofomycine
Glycopeptides
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2
Q

Exemples de b-lactames

A 
Penicillin 
Aztreozam
Cephalosporin
Imipenem
Vancomycin
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3
Q

AB agisant au niveau de la membrane cytoplasmic

A

Polymyxines

Thyrothrycines

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4
Q

Inhibiteurs de la sous unité 50S

A 
Phenicolé
Macrolides
Lincosamides
Streptogramines
Oxazolidinone
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5
Q

Inhibiteurs de la sous unité 30S

A

Tetracycline

Aminoglycosides

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6
Q

Inhibiteurs de l’enzyme ISOLEUCYL tRNA synthetase

A

Muciporine

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7
Q

Inhibiteur du metabolisme des acides nucleique

A 
Ansamycines
Quinolones
Fluoroquinolones
 sulfamide 
Diaminopyridine
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8
Q

Antimetabolites

A

Trimethoprime

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9
Q

Effet product par association de 2AB

A

Indifference
Addition
Synergies
Antagonisme

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10
Q

Types de resistances aux AB

A

Naturelle ou intrinseque

Acquise

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11
Q

Mecanismes biochimique de resistances

A

Defaut de penetration de AB dans la bacterie
Inactivation ou excretion de AB par des systemes enzymatiques bacteriens
Defaut d’affinité entre cible bacterienne et AB

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12
Q

Bactericidal drugs

A 
"Very Finely Proficient At Cell Murder"
            Vancomycin
            Fluoroquinolones 
            Penicillin 
            Aminoglycosides 
            Cephalosporins 
            Metronidazole
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13
Q

Bacteriostatic drugs

A 
ECSTaTIC
Erythromycin 
Clindamycin 
Sulphonamides
Tetracycline 
Trimethoprime 
Chloramphenicol
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14
Q

MIC

A

Minimum amount of drug needed that can inhibit growth within 15 to 20hrs

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15
Q

Unwanted effects of AB

A

Hypersensitivity rxn
Rxns due to toxic effects of AB
Super infections (2nd infection superimposed on earlier one)

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16
Q

Situations in which drug combinations are prescribed

A

To achieve broad antimicrobial activity
To treat mixed bacterial infections
To prevent emergence of resistance
To achieve an additive or synergistic effect

Antimicrobials (24 decks)

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