Lincosamides Flashcards

1
Q

Membres

A

Lincomycin

Clindamycin

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2
Q

MoA

A

Inhibiteurs de la synthese proteique par fixation a la ss 50S

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3
Q

Spectre d’activité

A

Gram+ aerobies et anaerobies
Mycoplasmes
Neisseria et haemophilus (gram-)

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4
Q

Clindamycin indications

A
Plus actif sur les anaerobies
 preferer pour traiter l'abces 
Toxoplasmes 
Prostatite 
Arthrite
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5
Q

Indication lincomycine

A

Infections des os de la peau et des tissu mou

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6
Q

Resistance

A

Bacterie a gram -

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7
Q

Effet indesirables

A
Diarhee severe 
Blocage neuromusculaire avec paralysie post anesthesique 
Depression cardiaque 
Allergies 
Degenerescence hepatiques moderé
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8
Q

Effet indesirables

A
Diarhee severe 
Blocage neuromusculaire avec paralysie post anesthesique 
Depression cardiaque 
Allergies 
Degenerescence hepatiques moderé
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9
Q

Interactions

A

Ils antagonise l’action des phenicolé et macrolides

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10
Q

Effet du kaolin sur la lincomycin

A

Reduit son absorption

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