Macrolides Flashcards

1
Q

Origine

A

Streptomyces erythreus

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2
Q

Membre d 1ere generation

A

Erythromycin A

Spiramycin

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3
Q

Membre de 2e generation

A

Josamycine

Medicamycine

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4
Q

Membre de la 3e generation

A

Erythromycin
Azithromycine
Clarithromycin
Roxithromycine

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5
Q

Autre membre

A

Ansamycin
Oleandromycine
Carbomycine
Tylocine

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6
Q

MoA

A

Altere la synthese proteique en se fixant sur la ss 50S

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7
Q

Indications cliniques

A
Infections ORL
angines
Infections pulmonaire
Infection cutanee 
Infection genital
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8
Q

Role de la clarithromycin dans le sida

A

AB le plus actif sur le Mycobacterium avium qui est le principal agent responsable des diarhee chronique dans linfection a vih

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9
Q

Role sur H.pylori

A

Efficaces Dans les traitement des ulceres duodenaux causer par H.pylori

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10
Q

Effets indesirables

A

Vomissement
Diarhee nausee allergies
Douleurs abdominale

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