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Antimicrobials > B-lactamines > Flashcards

B-lactamines Flashcards

1
Q

Membres de la classe des b-lactames

A 
Penicillin 
Cephalosporin 
Monobactames
Pénèmes (carbapeneme)
Inhibiteurs des b-lactamases
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2
Q

Membres de la classe des b-lactames

A 
Penicillin 
Cephalosporin 
Monobactames
Pénèmes (carbapeneme)
Inhibiteurs des b-lactamases
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3
Q

MoA b-lactamines

A

Inhibiteurs de la synthese de la paroi bacterienne

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4
Q

Effet

A

Bactericide

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5
Q

Cible des b-lactamines

A

Proteine liant les penicillin PLP ou

PBG

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6
Q

Facteurs influancant leur passage chez les bact. Gram-

A

Taille
Charge
La nature du lipopolysaccharide

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7
Q

Inhibiteurs b-lactamases role

A

Empecher l’inactivation des b-lactamines par les b-lactamases

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8
Q

Exemple inhibiteurs b-lactamases

A

Acide clavulanique
Tazobactam
Sulfabactam

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9
Q

Indications therapeutique Penicillin G

A

Angines aiguës a streptocoques (10jr)
Prevention des rhumatismes articulaires aiguës
Prophylaxie des infections a pneumocoque chez les splenectomisés

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10
Q

Penicillin M exemple

A

Oxacilline

Meticilline

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11
Q

Indications therapeutique Penicillin M

A

Infection qu staphylocoque
Septicemies
Infection osseuse et osteoarticulaire
Monotherapie dans les infections cutané

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12
Q

Penicillin A exemple

A

Amoxicillin

Ampicillin

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13
Q

Indications therapeutique Penicillin A

A

Meilleur activité sur les pneumocoque que Penicillin G
Infection des voies respiratoires
Meningite a Germes sensible
Infection urinaire

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14
Q

Indications therapeutique cephalosporin

A

Infections respiratoires de gravité moderer
Infection ORL
Pyelonephrite
Aplasie medullaire

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15
Q

1ere generation cephalosporin

A 
Parenteral:
            Cefazolin
            Cephaloridine
            Cephalothin
Oral:
       Cephalexin 
       Cephadroxil
P+O:
       Cephradine
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16
Q

1ere generation cephalosporin

A 
Parenteral:
            Cefazolin
            Cephaloridine
            Cephalothin
Oral:
       Cephalexin 
       Cephadroxil
P+O:
       Cephradine
17
Q

2e generation cephalosporin

A 
Parenteral:
          Cefamyxin C
          Cefoxitin
          Cefotitan
          Cefmetazole
Oral:
        Cefprozil
        Cefachlor
18
Q

3e generation cephalosporin

A 
Parenteral:
              Cefotaxime
              Ceftriazone
              Ceftazidime
Oral:
       Ceftibuten
19
Q

Effets indesirables touche 2 principaux tissu qui sont?

A

Moelle osseuse et sang

La peau

20
Q

Effets indesirables touchant la moelle

A

Anemie
Thrombopenie peripherique d’origine immunoallergique
Trouble de hemostase par diminution de l’aggregation plaquettaire

21
Q

Effets indesirables touchant la peau

A

Eruption maculo-papuleuse ou urticarienne associé a des adenopathies et de la fievre
Allergies et hypersensibilité

22
Q

Penicillin MoA

A

Binding to PBP
Block transpeptidases cross linking of cell wall
Activate autolytic enzymes

Antimicrobials (24 decks)

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