Medicaments Antituberculeux

Question 1

Xtic de la tuberculose

Answer 1

Chronique et necrosante

Transmissible et non-immunisante

Question 2

Agents causatif principal

Answer 2

Mycobacterium tuberculosis (bacile de koch

Question 3

Dieffernts especes de mycobacterium

Answer 3

Mycobacterium tuberculosis
Mycobacterium africanosis
Mycobacterium avium complex

Question 4

Therapie antituberculeuse (STRIPE)

Answer 4

Isoniazid
Rifampicine
Pyrazinamide

Streptomycine
Ethambutol

Question 5

Isoniazid (INH) effet

Answer 5

Bactericide sur baccilles intracellular et extracell

Question 6

INH spectre

Answer 6

Etroit

Question 7

INH demi vie

Answer 7

1-6h

Question 8

INH faux serique efficace

Answer 8

1-2ug/ml a la 3e hr

Question 9

INH elimination

Answer 9

Urinaire

Question 10

INH MoA

Answer 10

Inhibe la synthese de l’acide mycolique (constituent de la paroi mycobacterienne)
Source de monoxyde d’azote

Question 11

Effet secondaire INH

Answer 11

Trouble neurologique ou psychic

Hepatite

Question 12

Rifampicine proprietés

Answer 12

Bactericide a diffusion extra et intracell

Question 13

Rifampicine indications

Answer 13

Antituberculeux
AB actif sur la lepre;brucellose
Meningite a meningocoque

Question 14

Rifampicine MoA

Answer 14

Inhibe la synthese des acides nucleique en inhibant ARN polymerase

Question 15

Spectre rifampicine

Answer 15

Large : CG+

BG-

Question 16

Demi vie rifampicine

Answer 16

2-3h

Question 17

Elimination rifampicine

Answer 17

Biliaires

Question 18

Interactions medicamenteuse

Answer 18

Corticoïdes
Contraceptive steroidien
Hypoglycemiants
Anticoagulant oraux 
Cimetidine 
Quinidine
Ciclosporine

Question 19

Effet indesirables rifampicine

Answer 19

Intolerance digestive
Rash cutané
Fievre
Syndrome grippal 
Thrombopenie

Question 20

Pyrazinamide proprieter

Answer 20

Bactericide

Question 21

Demie vie pyrazinamide

Answer 21

10h

Question 22

Elimination pyrazinamide

Answer 22

Urinaire

Question 23

Metabolisme pyrazinamide

Answer 23

Hepatiques

Question 24

MoA pyrazinamide

Answer 24

Perturbation du transport memebranaire et de l’energetique de M.tuberculosis par l’acide pyrazinoïque

Question 25

Effets indesirables pyrazinamide

Answer 25

Rxn hypersensibilité Hepatotoxicité severe rare Arthralgies Hyperuricemie

Question 26

Ethambutol effet

Answer 26

Bacteriostatique sur baccilles extracell

Question 27

Demi vie ethambutol

Answer 27

4h

Question 28

MoA Ethambutol

Answer 28

Inhibiteurs de la synthese des composants de la paroi | Favorise penetration d'autres Antituberculeux

Question 29

Contre indications Ethambutol

Answer 29

Nevrite optique preexistante Clairance de la creatine inferieure a 50ml/min Enfant trop jeune

Question 30

Effets indesirables Ethambutol

Answer 30

Baisse de l'acuité visuelle entrainer par une nevrite optique et risque de cecité Signe de nevrite peripherique Dan's les jambes

Question 31

Streptomycine effet

Answer 31

Bactericide sur baccilles extracell

Question 32

Demi vie streptomycine

Answer 32

2 a 3h

Question 33

Contre indications streptomycine

Answer 33

Grossesse

Question 34

Effet indesirables streptomycine

Answer 34

L'abces steriles au points dinjection Cephalees vomissement vertiges acuophene Chute de la diurese d'albuminurie presence des cylindre Dan's les urines

Question 35

Interactions medicamentuese streptomycine

Answer 35

Ne pas administrer d'autres medicaments ototoxique ou nephrotoxique en meme temps k la streptomycine

Question 36

Exempls des medicaments nephrotoxique et ototoxique

Answer 36

Aminoside Cephalosporins Vancomycin