Quinolones Flashcards
First generation
Naldixic acid
Second generation
pipemidic acid
Third generation
Ciprofloxacin ,ofloxacin ,levofloxacin
Fourth generation
Moxifloxacin ,trovafloxacin
Mechanism of action of Quinoline
Inhibit action of DNA Gyrase ,Topoisomerase 4
Quinolones are bactericidal
True
Spectrum of first and second Quinolones generation
Negative bacteria
Spectrum of Quinoline 3 RD generation
Gram positive, negative
Spectrum of fourth generation Quinolone
Against Gram positive, anaerobe
……. generation is used for systemic infection
3rd
…..,…. Are known as respiratory Quinolones
Levofloxacin , Moxifloxacin
Atypical respiratory pathogens
Leĝionella ,mycoplasma
Co trimoxazole is mix between….,…..
Sulfamethoxazole ,trimethoprim
Spectrum of sulfonamide ,trimethoprim
Gram positive ,some gram negative
Salmonella in fection treated by
Co trimoxazole