CNS 3 Flashcards
Propoxyphene compared to codeine ( anti ,tissuve effect - respiratory depression
Equal to codeine anti tussive effect
⅓ respiratory center depression of codeine
In chronic toxicity of morphine we use …..as atreat ment
Methadone
Colinidine
Sedative :diazepam
Syndrome result from gradual withdrawal of morphine
Abstinence syndrome
Methadone is given …….orally
Full antagonist of opoid receptors
Naloxone ,naltrexone
Naloxone is given ….1.,but naltrexone is given ..2.
1-I.V
2- orally
Uses of Naloxone, naltrexone
Acute toxicity ,during labour
How to deal with mother addict morphine during labour
We give Naloxone to the neonate via umblical vein ,and its contraindicated to give Naloxone to this mother
Partial agonists
Nalorphine ,nalbuphine
Pentazocine,butorphanol
Buprenorphine
What is the properities of pentazocine and butorphanol
Increase systemic pulmonary artery pressure so contra indicated in coronary ischemia
Doesn’t cause withdrawl effect
Non selective cox inhibitors has salicylic acid derivatives
Asprin
Non selective cox inhibitors carboxylic acetic acid
Indomethacin
Non selective cox inhibitors phenyl acetic acid
Diclofenac
Non selective cox inhibitor propionic acid derivatives
Iboprufen, naproxen
non selective cox inhibitors oxicams
Piroxicam