Ans1 Flashcards

1
Q

What is the organs have alpha1 receptos?

A

1, most vascular smooth muscles
2_smooth muscles of git,urinary system.
3-pupillary dilator ms.

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2
Q

What is the organs organs that have beta1 blockers?

A

Heart,kidney

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3
Q

What is the organism that have alpha 2 receptors?

A

Adrenergic and cholinergic nerve terminals.

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4
Q

What is the organ that have beta 2 receptor?

A

1-respiratory system. Broncodilatation.
2- uterine ,and vascular smooth ms
3-liver to increase glycogenolysis.

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5
Q

what is the organs that have M1 receptors?

A

1- Stomach to increase Hcl

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6
Q

M2 receptors exist in :

A

1-Heart to decrease heart activit.

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7
Q

Type of autonomic receptor in uterine

A

Beta 2

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8
Q

Type of autonomic receptor in the it is the respiratory system

A

beta2

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9
Q

Type of sympathetic resptors in GIt ,and gall bladder

A

Alpha1

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10
Q

What are the organs that have M3 receptors

A

1- smooth ms of GIT , urinary system…contraction
2-Blood vessels……..V.c
3- Bronchoconstriction

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11
Q

in Thyrotoxicosis increased sensitivity of ……..

A

Beta receptors

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12
Q

متي نستخدم الnourepiniphrine

A

acute hypotensive states as spinal anthesis

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13
Q

كيف نعطي الأدرينالين والنور ادرينالين

A

1-adrenaline :I.m or sc or topically
I V in cases of cardiac arrest
2- noradrenaline :l.v by fusion (caution)

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14
Q

Selective Beta1 agonst is

A

Dobutamine

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15
Q

Selective beta 2 agonists is :

A

Salbutamol,terbutaline,salmetrol ,ritodrine

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16
Q

A Drug used to induce uterine relation and delay preterm labour

A

Ritodrine

17
Q

Alpha adrenoreceptor agonists are:

A

Phenylephrine,methoxamine ,medodrine

18
Q

Fate of adrenaline and nore adranaline:

A

1-reuptake %80
2 -20% metabolism

19
Q

What are the enzymes response responsible for metabolize of adrenaline and Nore adrenaline?

A

MOA:monoamine Oxidase.
COMT:Catechol O methyl trasfese

20
Q

Tyes of autonomic resptors in the heart

A

Sympathetic: beta one
But a sympathetic:m2

21
Q

What are adverse effects of adrenaline,

A

Adverse effects

• Rise in blood pressure,

• Anginal pain from excessive cardiac work and strain.

• Arrhythmia.

• Cerebral hemorrhage.

• Sever vasoconstriction resulting in gangrene of extremities and tissue necrosis with repeated administration.

22
Q

What ere the contra indications of adrenaline,

A

• Hypertension.

Ischemic heart disease.

• Arrhythmia or with digitalis: epinephrine can worsen the arrhythmia and even precipitate ventricular fibrillation.

Thyrotoxicosis: because patients with thyrotoxicosis have increased sympathetic overactivity (tachycardia, tremors, anxiety, etc) due to increased sensitivity of ẞ receptors.

23
Q

Effect of adrenaline in the eye:

A

Contraction of pupillary ms (mydrasis)
Reduce intraocular pressure

24
Q

In the anaphlactic shock adrenaline reduce bronchial secretion by ….1..
And cause b.d through….2… receptos

A

1 alpha one
2 beta 2

25
Q

The dose of adrenaline in anaphylactic shock and the adminstration

A

Dose: 0.5ml (1:1000)
Adminstration I.m

26
Q

لماذا نستخدم الادرينالين مع المخدرات الموضعيه؟

A

Diluted concentration (1:10000)
V.c ~reduce absorption & prolong
Reduce bleeding

27
Q

Drug that we can’t use adrenaline with

A

Digitalis

28
Q

ليه مينفعشي ندي noreadrenalinr
Orally
S.c
I.m

A

Orally :not absorbed
S.c or I.m severe v.c and may cause ncrosis