Aminoglycosides

Question 1

Family

Answer 1

Gentamicin, tobramycin , streptomycin ,

Question 2

MOA of aminoglycosides

Answer 2

Irreversible inhibition of protein synthesis 30s

Question 3

Aminoglycosides (cidal or static )?

Answer 3

Cidal

Question 4

Spectrum of aminoglycosides

Answer 4

Gram negative bacteria , pseudomonads
Few gram positive as viridans

Question 5

Pharmacokinetics properties of aminoglycosides

Answer 5

Oral absorption is poor due to ,it converted to ions

Question 6

What is the uses of aminoglycosides ?

Answer 6

1- gentamycin wth ampicillin in endocarditis
2-Combined with pencillin for septicemia
Antispeudomonas with pencillin
Topical use

Question 7

What; s the adverse effects of aminoglycosides

Answer 7

Nephrotoxicity
Ototoxicity
Neuromuscular blocker

Question 8

What is the spectrum of tetracycline

Answer 8

Broad spectrum gram +ve ; -Ve
Atypical bacteria.

Question 9

Tetracycline is (static /cidal

Answer 9

Static

Question 10

Absorption of tetracycline

Answer 10

Partially absorbed due to chelation effect

Question 11

Excretion of Doxycycline

Answer 11

Through bile

Question 12

Uses of tetracycline

Answer 12

Peridontal infection
Intraoral herps infection
Apthous ulcer to prevent 2ry infection

Question 13

Most common side effects of tetracycline

Answer 13

Vitamin B12 deficiency
Stainig of teeth
Photosensitivity
GIT Disorders

Question 14

What is the MOA of linezolid

Answer 14

50 s subunits

Question 15

Linezolid (cidal/static)

Answer 15

Cidal

Question 16

What is the uses of linzeloid

Answer 16

Against gram psitive cocci ,
VRSA,MRSA

Question 17

What is the route of adminstration of linezolid

Answer 17

Oral
Parentral

Question 18

What is the adverse effects of linzeloid

Answer 18

Thrombocytopenia
Neutropenia
GIT disturbance