Anti Fungal Drugs Flashcards
Mechanism of action of amphotricin
Bind firmly to ergosterol . Of cell membrane
Amphotricen B spectrum
Broad spectrum
The drug of choice for most systemic mycosis
Amphotricin B
Route of amphotricin B
Intravenous for systemic
Locally for treatment cutaneous , mucocutaneous, as lozenges
Type of anemia cuased by Amphotricin B
Normochromic Normocytic anemia
Amphotricin B cuase hypokalemia
T
Anti fungal cuase ms spasm
Amphotrin B
Anti fungal cuase ms spasm
Amphotrin B
Flucytosine mechanism of action
Is converted to 5 fouro uracil which inhibit DNA synthesis
Uses of flucytosine
Systemic infection
Adverse effects flucytosine
Bone marrow depression.
Hepatic dysfunction .
Azoles are broad spectrum
True
Bioavailability of azoles depend on gastric Hcl except
Fluconazole
Bioavailability of azoles depend on gastric Hcl except
Fluconazole
Mechanism of action of azoles
Bind with fungal cell membrane, inhibit …..
By inhibiting …..
For treatment of pesudomembranous candidates, Denture stomatitis
Oral fluconazole .
Miconazole gel .
For angular cheilitis treatment we use
Miconazole cream
Azoles has anti anderogenic side effect
Ketoconazole
Azoles has anti anderogenic side effect
Ketoconazole
Azole decrease sperm count of sperm
Ketoconazole
Ketoconazole cuase fluid retention
True
Nystatin
Orally …….
Parentral……..
Route of administration…..
Not absorbed .
Too toxic .
Cream suspension
Uses of Nystatin
Oropharyngeal monillia
Angular cheilits
Acyclovir
mechanism
Route
Excretion
Inhibit DNA polymerase
Oral ,I.V ,Topically
Kidney
