Anti Fungal Drugs Flashcards

1
Q

Mechanism of action of amphotricin

A

Bind firmly to ergosterol . Of cell membrane

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2
Q

Amphotricen B spectrum

A

Broad spectrum

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3
Q

The drug of choice for most systemic mycosis

A

Amphotricin B

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4
Q

Route of amphotricin B

A

Intravenous for systemic
Locally for treatment cutaneous , mucocutaneous, as lozenges

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5
Q

Type of anemia cuased by Amphotricin B

A

Normochromic Normocytic anemia

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6
Q

Amphotricin B cuase hypokalemia

A

T

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7
Q

Anti fungal cuase ms spasm

A

Amphotrin B

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8
Q

Anti fungal cuase ms spasm

A

Amphotrin B

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9
Q

Flucytosine mechanism of action

A

Is converted to 5 fouro uracil which inhibit DNA synthesis

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10
Q

Uses of flucytosine

A

Systemic infection

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11
Q

Adverse effects flucytosine

A

Bone marrow depression.
Hepatic dysfunction .

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12
Q

Azoles are broad spectrum

A

True

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13
Q

Bioavailability of azoles depend on gastric Hcl except

A

Fluconazole

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14
Q

Bioavailability of azoles depend on gastric Hcl except

A

Fluconazole

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15
Q

Mechanism of action of azoles

A

Bind with fungal cell membrane, inhibit …..
By inhibiting …..

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16
Q

For treatment of pesudomembranous candidates, Denture stomatitis

A

Oral fluconazole .
Miconazole gel .

17
Q

For angular cheilitis treatment we use

A

Miconazole cream

18
Q

Azoles has anti anderogenic side effect

A

Ketoconazole

19
Q

Azoles has anti anderogenic side effect

A

Ketoconazole

20
Q

Azole decrease sperm count of sperm

A

Ketoconazole

21
Q

Ketoconazole cuase fluid retention

A

True

22
Q

Nystatin
Orally …….
Parentral……..
Route of administration…..

A

Not absorbed .
Too toxic .
Cream suspension

23
Q

Uses of Nystatin

A

Oropharyngeal monillia
Angular cheilits

24
Q

Acyclovir
mechanism
Route
Excretion

A

Inhibit DNA polymerase
Oral ,I.V ,Topically
Kidney