Macrolides Flashcards
Macrolide family
Clarithromycin ,azithromycin
Erythromycin (protype)
What is the spectrum of macrolides
Similar to pencillin G
Drug is bacteriostatic in low concentration,but in high concentration is bactericidal
Erythromycin
Food interfere with …..drug from macrolide
erythromycin
Macrolide has short duration
Erythromycin
What is the uses of macrolide
Gram positive
Atypical bacteria
H .pylori
Drug used for treatment of H.pylori
Clarithromycin
All macrolide cause inhibition of microsomal p450 except
Azithromycin
Clindamycin spectrum
Similar to erythromycin , against gram +ve
Many anaerobic bacteria
1st choice of gram anaerobic bacteria
Clindamycin,
Clindamycin adminstration
Oral parentral
Distribution of clindamycin
Widely distributed in all body tissue
Including bone ,fluids
What is uses of clindamycin
In replacement of pencillin in endocarditis
1st choice
We can treat pseudomembranous colitis by …….
Vancomycin, metronidazole
What is the uses of fusidin
50 s
+Ve
Wide distribution in bone ,tissue
