Purine Synthesis and Salvage Pathway 💡 Flashcards
De Novo Purine Biosynthesis
The process of synthesizing purine nucleotides from scratch, involving specific amino acids, formyl tetrahydrofolate, and energy sources.
Sulfonamide/ Sulfa drugs
Antibacterial agents that inhibit bacterial folate synthesis
Methotrexate
Folate analog used as an anticancer agent by competitive inhibition of dihydrofolate reductase
Ribose Phosphate
Key component in PRPP synthetase for purine nucleotide synthesis
Trimethoprim
Inhibitor of bacterial dihydrofolate reductase
Folic acid synthesis
Essential process in microorganisms, involves PABA analogs
Salvage pathway of purines
Process to recycle purine bases for nucleotide synthesis, important for brain function
Purine
Purines are nitrogenous bases like adenine and guanine, essential components of nucleotides for DNA and RNA synthesis.
IMP
Inosine monophosphate (IMP) is a key intermediate in purine biosynthesis, further converted into AMP and GMP with the use of ATP and GTP.
Ribonucleotide reductase
Enzyme that converts ribonucleotides to deoxyribonucleotides for DNA replication
Lesch-Nyhan syndrome
X-linked recessive disorder characterized by severe intellectual disability, self-mutilation, and elevated uric acid levels
HGPRT
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme that catalyzes important reactions in purine salvage pathways.
PRPP
Phosphoribosyl pyrophosphate (PRPP) is a key molecule in nucleotide synthesis, serving as an essential precursor for purine and pyrimidine biosynthesis.
Thiopurine and azathioprine
Metabolized to inhibit de novo purine synthesis, used as anticancer and immunosuppressive agents
Folate deficiency
Leads to macrocytic anemia and decreased cell division, critical in DNA synthesis
