Designing a Rational Dosage Regimen 💊 Flashcards
Slow release formulation
A type of drug formulation that results in delayed peak concentration, lower peak levels, and higher drug levels at later times, allowing for less frequent drug administration.
Clinical Pharmacokinetics
The study of drug movement throughout the body, including the processes of absorption, distribution, metabolism, and excretion.
Maintenance Dose
The amount of drug needed to maintain a steady concentration in the body by replacing the drug eliminated since the last dose.
Therapeutic Window
The range of acceptable plasma levels of a drug when designing a dosing regimen to achieve the desired therapeutic effects.
Loading Dose
An initial high dose of a drug given to achieve a rapid target concentration, especially useful when loading the volume of distribution with the drug.
Steady State
A state where the rate of drug intake equals the rate of drug elimination, leading to a constant drug concentration in the body.
Drug Accumulation
The process where drug doses accumulate in the body when given repeatedly, with the accumulation factor determining the final drug concentration.
Accumulation
The process of a drug reaching higher levels in the body over time due to repeated dosing or slow elimination.
LD=VdxPCss
The formula for calculating the loading dose with intermittent dosing, where LD is the loading dose, Vd is the volume of distribution, and PCss is the peak concentration at steady state.
Oral administration
The method of drug administration through the mouth, yielding a more rounded peak in plasma concentration compared to IV administration.
LD=Maintenance Dose x Accumulation Factor
The formula for calculating the loading dose when the accumulation factor for a drug given once every half-life is 2, making the loading dose twice the maintenance dose.
