Pulmonary Pathology Flashcards
dynein motors are driven by
- ATP
pathogenesis of bronchiectasis
- impaired mucus flow
- microbial colonization
- microbial products leading to damage and mucus hypersecretion
pathogenesis of cystic fibrosis
- failed chloride pump leaves mucus dehydrated so iyou can’t move it
PCD structure of cilia
- normal 9+2 structure
- no dynein arms
Charcot Leyden Crystals and Curschmann Spirals are seen in what condition
- asthma
what are Charcot Leyden crystals
- degranulated eosinophils
pathology of chronic bronchitis
- mucous cellular and glandular hyperplasia (increase in number and size and produce more mucous)
- submucosal chronic inflammation
two major categories of emphysema
- cigarette smoking
- alpha 1 antitrypsin deficiency
upper lobe emphysema is what type
caused by
- centrilobar
- cigarette smoking
lower lobe emphysema is what type
caused by
- panlobar
- alpha 1 antitrypisin deficiency
big pathology of emphysema
- increased elastase activity in the lung
how cigarette smoking contributes to emphysema
- generates more elastase and inhibits alpha 1 antitrypsin which normally inhibits elastase
how alpha 1 antitrypsin deficiency contributes to emphysema
how
- can’t inhibit elastase
- alpha 1 antitrypisin is stuck in the rER of hepatocytes
alpha 1 antitrypsin deficiency genetic pattern
deficiency in which gene
most common allele
- autosomal recessive
- loss of function in SERPINA1
- Z
BOOP (bronchiolitis obliterans/organizing pneumonia) symptoms
- acute cough
- dyspnea
- fever
- malase
