Pulmonary Hypertension Flashcards
1
Q
7 subtypes of group 1 PHTN
A
- Idiopathic
- Heritable
- Drug and Toxin induced
- PAH associated with
- Connective tissue disease
- HIV
- Portal HTN
- Congenital heart disease
- Schistosomiasis
- PAH long-term responders to CCBs
- PAH with overt features of venous/capillaries involvement (PVOD/PCH)
- Persistent PHTN of the newborn syndrome
2
Q
4 subtypes of group 2 PHTN
A
- HFpEF
- HFrEF
- Valvular heart disease
- Congenital/Acquired cardiovascular conditions leading to post-capillary PHTN
3
Q
5 subtypes of group 3 PHTN
A
- Obstructive lung disease
- Restrictive lung disease
- Mixed disease
- Hypoxia without lung disease
- Developmental lung disorders
4
Q
2 subtypes of group 4 PHTN
A
- CTEPH
- Other pulmonary artery obstructions
5
Q
4 subtypes of group 5 PHTN
A
- Hematologic disorders
- Systemic and metabolic disorders
- Others
- Complex congenital heart disease
6
Q
Hemodynamics of pre and post capillary PHTN
A
7
Q
Calculation for Transpulmonary Gradient (TPG)
A
TPG = MPAP - PCWP
8
Q
PVR calculation formula
A
PVR = TPG/CO
9
Q
Gene mutation responsible for 75% of heritable PAH
A
BMPR2
10
Q
Genes associated with hereditary hemorrhagic telangiectasia and PAH
A
Alk-1
SMAD9
Endoglin
11
Q
Gene mutation found in PAH from PVOD or PCH
A
EIF2AK4
12
Q
Most common connective tissue disease in PAH
A
Scleroderma
13
Q
DETECT algorithm for performing RHC in scleroderma
A
Get if any of the following:
- TTE changes
- FVC/DLCO ratio > 1.6
- > 2 fold upper limit of normal NT-Pro-BNP
14
Q
PAH is an independent risk factor for death in what disease?
A
HIV
15
Q
Echo criteria for RHC in portopulmonary HTN
A
- Tricuspid jet > 3.4
- RA enlargement
- RV enlargement or dysfunction
