Fungal Organism Treatments

Question 1

Aspergillus first line therapy

Answer 1

Voriconazole or Isavuconazole

Question 2

Mucor first line therapy

Answer 2

Amphotericin B

Question 3

Fusarium first line therapy

Answer 3

Amphotericin B

Question 4

S. Aspiosermum first line therapy

Answer 4

Voriconazole

Question 5

L. prolificans first line therapy

Answer 5

Voriconazole

Question 6

Aspergillus second line therapy

Answer 6

Posaconazole or itraconazole

Question 7

Mucor second line therapy

Answer 7

Posaconazole

Question 8

Treatment for severe blastomycosis

Answer 8

Ampho B 1-2 weeks, then itraconazole

Question 9

Treatment for mild to moderate blastomycosis

Answer 9

Itraconazole 6-12 months

Question 10

Treatment for blasto with CNS disease

Answer 10

Ampho B

Question 11

Treatment for blasto in pregnancy

Answer 11

Ampho B (No Azoles)

Question 12

Treatment for invasive candidemia

Answer 12

Echinocandins over azoles initially, can switch later

If candidemia alone, 2 weeks from negative culture

If endopthalmitis, 4-6 weeks

Question 13

Treatment for coccidioidomycosis

Answer 13

• Immunocompetent: observation (90% self limited)
• If sxs > 6 weeks, consider treatment
• Immunosuppressed
  
  • Fluconazole
  • Amphotericin

Question 14

Treatment of cryptococcus

Answer 14

Lung: Fluconazole

CNS: Ampho + flucytosine

Question 15

Treatment for histoplasmosis

Answer 15

• Mild or chronic: Observation
• Moderate: Itraconazole
• Severe: Ampho