Pulmonary

Question 1

Paraneoplastic Syndromes in Small cell CA

Answer 1

Cushing’s, SIAD, Hypercalcemia, Lambert-Eaton, Acanthosis Nigerians, hypertrophic osteoarthropathy, venous thrombosis

Question 2

ARDS

Answer 2

Pathology: leukocyte mediated injury to alveolar capillaries
Histology: hyaline membrane in septa (diffusion barrier)

Question 3

Centriacinar Emphysema

Answer 3

• Smokers

- Affects respiratory bronchioles

Question 4

Panacinar (panlobular) Emphysema

Answer 4

• A1AT Deficiency
• Affects resp bronchiole and alveoli
• More commonly in lower lobes

Question 5

ANCA

Answer 5

Anti Neutrophilic Cytoplasmic Ab

• P-ANCA: Ab against MPO in cytoplasm of neutrophils
• C-ANCA: Ab against proteinase 3 in cytoplasm of neutrophils

Question 6

Adenocarcinoma in situ (Lung)

Answer 6

Lepidic growth of glandular tissue, grows along septa (butterflies on a fence thing)

Question 7

Hypersensitivity Pneumonitis

Answer 7

aka Farmer’s Lung
Pathogenesis: type III hypersensitivity
Exposure: moldy hay

Question 8

Pulmonary HTN

Answer 8

Primary: BMPR2 gene mutation
Morphology: plexiform lesions

Question 9

Lamellar bodies

Answer 9

Store surfactant

Question 10

Adenocarcinoma complication

Answer 10

Beck’s triad

KRAS mutation in smokers, EGFR and ALK

Question 11

Bronchial carcinoid ca

Answer 11

Grow in polypoid fashion