Ovary Path Flashcards
Follicular/Luteal Cyst
Pathogenesis: unruptured follicle or follicles that have ruptured and become resealed
Morphology: filled w/ clear serous fluid (small - lined by granulosa or luteal cells)
ROS: if large enough mall palpable w/ pelvic pn
Chocolate Cysts of Ovary
Etiology: caused by endometriosis
Pathogenesis: repeated cyclical hemorrhage = brownish color; induces fibrosis and adhesions
H&E: nml glands + stroma + RBCs + hemosiderin
ROS: assoc w/ infertility
Meigs Syndrome
Fibroma (thecoma) + ascites + hydrothorax
Ovarian tumor assoc. w/ Lynch syndrome?
Endometroid (surface epithelial)
Gross: small, solid cystic mass, papillae, velvety surface
Surface epithelial tumors?
Serous (psammoma bodies - CA125)
Mucinous (jelly belly - CA125)
Endometroid (HNPCC)
Brenner (bladder ep)
Germ cell tumors?
Teratoma
Dysgerminoma
Choriocarcinoma
Yolk sac (endodermal sinus)
Sex cord stromal tumors?
Granulosa cell tumor
Fibrothecoma
Fibroma
Granulosa cell tumor
Produces estrogen (can lead to endometrial ca or breast ca)
Biopsy: call-exner bodies, nests of polygonal cells w/ coffee bean nucleus and eosinophilic cytoplasm containing inhibin
Marker: inhibin
ROS: precocious puberty
Carcinoid teratoma
Arises from neuroendocrine cells, produces serotonin
Markers: synaptophysin, chromogranin, CD56
ROS: diarrhea, flushing, wheezing
Labs: 5-HIAA or 5-HT in urine
Dysgerminoma of ovary
Risk: Turner’s syndrome
Biopsy: fried egg w/ lymphocytic infiltrate
Marker: LDH
*analogous to seminoma testes
Ovarian choriocarcinoma
Non-gestational so doesn’t respond to chemotherapy (no paternal ag)
ROS: young female w/ +ve pregnancy test, morning sickness bc of elevated β-hCG
Marker: β-hCG
Biopsy: no chorionic villi, multinucleated syncytiotrophoblasts and mononucleated cytotrophoblasts
Labs: elevated CGT (β-hCG) in blood and urine
Yolk sac tumor
Germ cell
Biopsy: Schiller-Duvall bodies (malignant cells forming “glomeruli”), papillary projections w/ eosinophilic cytoplasm
Marker: AFP and α1AT
