Immunopath Flashcards

1
Q

Sjogren’s Syndrome

A

Anti-SSA Ab and Anti-SSB Ab
ROS: dry eyes and dry mouth (bc Ab’s attack lacrimal and parotid)
Schirmer’s test: filter paper under eye and it never becomes wet

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2
Q

Limited Scleroderma (CREST Syndrome)

A

Anti-centromere Ab

ROS: calcinosis, raynaud’s, esophageal dysmotility, sclerodactyly, telangectasia

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3
Q

SLE

A

Anti-dsDNA and Anti-Smith Ab (Anti-nuclear Ab is non-specific) also Anti-phospholipid Ab

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4
Q

Wiskott Alderidge Syndrome

A

Deletion: WASP gene
ROS: thrombocytopenia, eczema, recurrent pyogenic infections

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5
Q

Ataxia Telangectasia

A

Gene: ATM
ROS: recurrent infections, ataxia, angiomas, low IgA

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6
Q

Hyper IgM Syndrome

A

Defect: CD-40L on T cells

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7
Q

Diffuse/Systemic Scleroderma

A

Anti-scl70 Ab

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8
Q

Hyperacute Host v. Graft

A

Type II, w/in 24h, pre-existing host Ab’s react w/ graft

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9
Q

Acute Host v. Graft

A

Type II and IV, days to wks, Ab’s formed after transplant and T-cells too

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10
Q

Chronic Host v. Graft

A

Type IV, months to years, CD4+ T-cells of host

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11
Q

Graft v. Host

A

Grafted T-cells react to the host, happens in liver transplant and BMT bc they are hematopoietic

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