Immunopath

Question 1

Sjogren’s Syndrome

Answer 1

Anti-SSA Ab and Anti-SSB Ab
ROS: dry eyes and dry mouth (bc Ab’s attack lacrimal and parotid)
Schirmer’s test: filter paper under eye and it never becomes wet

Question 2

Limited Scleroderma (CREST Syndrome)

Answer 2

Anti-centromere Ab

ROS: calcinosis, raynaud’s, esophageal dysmotility, sclerodactyly, telangectasia

Question 3

SLE

Answer 3

Anti-dsDNA and Anti-Smith Ab (Anti-nuclear Ab is non-specific) also Anti-phospholipid Ab

Question 4

Wiskott Alderidge Syndrome

Answer 4

Deletion: WASP gene
ROS: thrombocytopenia, eczema, recurrent pyogenic infections

Question 5

Ataxia Telangectasia

Answer 5

Gene: ATM
ROS: recurrent infections, ataxia, angiomas, low IgA

Question 6

Hyper IgM Syndrome

Answer 6

Defect: CD-40L on T cells

Question 7

Diffuse/Systemic Scleroderma

Answer 7

Anti-scl70 Ab

Question 8

Hyperacute Host v. Graft

Answer 8

Type II, w/in 24h, pre-existing host Ab’s react w/ graft

Question 9

Acute Host v. Graft

Answer 9

Type II and IV, days to wks, Ab’s formed after transplant and T-cells too

Question 10

Chronic Host v. Graft

Answer 10

Type IV, months to years, CD4+ T-cells of host

Question 11

Graft v. Host

Answer 11

Grafted T-cells react to the host, happens in liver transplant and BMT bc they are hematopoietic