Pulmonary Flashcards
Obese patient HTN
Look for sleep apnea
Trousseau syndrome
Malignancy with recurrent PEs
Malignant HTN
Papilleda
Pulmonary hypertension
> 25 mm at rest
Pulmonary hypertension
Primary
Secondary
Eisenmenger PFO closure
Helps in some cases
Pulm HTN idiopathic
Autosomal dominant
Abnormal Bone marrow protein receptor
Drug induced pulm HTN
Aminorex
Fenfen
Amphetamine
Increases serotonin
Pm HTN associated with
Lupus Scleroderma HIV Portal HTN Eisenmenger Schistosomiasis
Venoocclusive
Male female 1:1 Genetic Imminogenic Bleomycin Diffuse occlusion of pulm veins Severe pulm HTN pulm edema elevated LVEDP Death in 2 years prostacyclins worsen No Bosentan
Pulm HTN due to left heart disease
No prostacyclins
Pulm HTN due to hypoxia
Copd
ILD
Sleep apnea
Pulm veno occlusive
Make female 1:1
Severe pulm HTN pulm edema and elevated EDP
Death in 2 yrs
Prostacyclin may worsen the condition
No Bosentan
Chronic thromboembolic pulmonary hypertension
Progressive dyspnea Chest pain Exertional intolerance Syncope Pedal edema Best test is VQ scan Ct angiography Pulm angio
chronic thromboembolic pulm HTN
Peri op mortality 4%
Pulm HTN other causes
Splenectomy
Sarcoidosis
Dialysis
Pulm HTN
Angina due to sub endo RV is bad sign
P2 wise split
VCR enlarged PA
Oligemic lung fields
RSVP =4x TRV2+RA pressure
Pulm HTN tests
HIV Liver ANA, ANCA. ,bnp Sleep study Exercise test 6min walk
Pulm HTN
Right heart cath
Mean PAP >25 mm
Group 2 has high LVEDP over 15
Pul HTN treatment
Group 1 IPAH no treatment Group 2 left heart treat CHF Group 3 hypoxemia Group 4 thromboembolic anticoag and surgery Group 5 underlying cause
Pulm HTN respond to nitric oxide
Treat with ca blockers
Pulm HTN no response to nitro up
Iloprost inhalation 6-9x a day
Flolan iv 1-4 weeks diarrhea flushing
Bosentan endothelial antagonist improved exercise hepato toxic
62.5 bid
Sildenafil improves exercise and oxygenation can be additive
Pulm HTN
Atrial septatomy 15-20% mortality
Transplant
PE
Mortality 30% RV dysfunction High bnp Pulm embolism severity index -pesi Age>80,cancer, copd, high hr,low BP , low sat 0 point 1% mortality One or more 10%
PE risk
DVT
Surgery
Immobilization obesity
Smoking
Symptoms
33% a symptomatic
Wells criteria
DVT 3 points No explanation 3 points Tachycardia 1.5 Immobility surgery 1.5 H/o DVT 1.5 Hemoptysis 1 Cancer 1 Score 6 high prob 2 low prob
PE
Tropinin high 30-50%
Normal D dimer in low to moderate probability excludes PE
PE echo
30-40% abnormal
Decrease RV function and increase RV size
Warfarin induced skin necrosis
In protein C deficiency
First PE
3-6 mos provoked
Unprovoked and recurrent indefinite Coumadin therapy
Thrombolysis PE
Severe hypoxemia Large PE RV dysfunction Free floating thrombus PFO
Cpap
26% at risk Ahi total number of apnea and hypoapnea per hour Mild 5-15 Moderate 15-30 Severe >30