Pulm - Restrictive Disease Flashcards
What category of pulmonary diseases is characterized by interstitial fibrosis due to occupational exposure?
Pneumoconioses
Pneumonconioses are caused by chronic exposure to ________genic particles engulfed by _____________.
Pneumonconioses are caused by chronic exposure to fibrogenic particles engulfed by alveolar macrophages.
Name four types of pneumoconiosis:
- _____________ pneumoconiosis
- Silicosis
- Beryllosis
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- Beryllosis
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- ___________
- Beryllosis
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- Beryllosis
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- ___________
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- Beryllosis
- Asbestosis
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- Beryllosis
- ___________
Name four types of pneumoconiosis:
- Coal workers’ pneumoconiosis
- Silicosis
- Beryllosis
- Asbestosis
Name the major occupation(s) associated with carbon dust exposure.
Coal mining
(coal workers’ pneumoconiosis)
Name the major occupation(s) associated with silica exposure.
Sandblasters;
silica miners
Name the major occupation(s) associated with beryllium exposure.
Beryllium miners;
the aerospace industry
Name the major occupation(s) associated with asbestos exposure.
Construction workers;
plumbers;
shipyard workers
How does coal miners’ pneumoconiosis appear in the lung tissue?
Diffuse fibrosis
(‘black lung’)
Coal miners’ pneumoconiosis is associated with ___________ arthritis in ___________ syndrome.
Coal miners’ pneumoconiosis is associated with rheumatoid arthritis in Caplan syndrome.
How does silicosis appear in the lung tissue?
Fibrotic nodules in the upper lobes
How does berylliosis appear in the body tissues?
Noncaseating granulomas in the lungs, hilar lymph nodes, and systemic organs
How does asbestosis appear in the pulmonary tissues?
Fibrotic lung/pleural plaques
Mild exposure to carbon results in __________sis, collections of carbon-laden macrophages which are not clinically significant.
Mild exposure to carbon results in anthracosis, collections of carbon-laden macrophages which are not clinically significant.
Silicosis increases risk of ___________sis.
Silicosis increases risk of Tuberculosis.
How does silicosis cause its fibrotic changes?
Impaired phagolysosome formation in macrophages
True/False.
Beryllosis increases risk of lung cancer.
True.
Describe the asbestos bodies associated with asbestos lesions.
Long, golden-brown fibers associated with iron
What size of particles are most dangerous to our lungs when inhaled?
1 - 5 microns
List the following pneumoconioses in order of increasing carcinogenicity:
Silicosis, berylliosis, asbestosis, coal worker’s
List the following pneumoconioses in order of increasing carcinogenicity:
Berylliosis, coal worker’s, silicosis, asbestosis
Inhalation of fibrogenic particles (e.g. in pneumoconioses) causes a release of what fibrogenic cytokines?
TGF-beta,
IL-6,
ROS
Name the three acute forms of intrinsic restrictive lung disease that are all manifestations of diffuse alveolar damage.
ARDS (adults);
neonatal respiratory distress syndrome (infants);
acute interstitial pneumonia (no identifiable cause)
