Pulm - Infectious Disease Flashcards

1
Q

What is pneumonia?

A

Infection of the lung parenchyma

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2
Q

What are the three main pattern types seen on CXR in patients with pneumonia?

A

Lobar;

bronchopneumonia;

interstitial

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3
Q

What are the two most common causes of lobar pneumonia?

(Give percentages for the two.)

A

S. pneumoniae (95%);

Klebsiella pneumoniae (5%)

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4
Q

Bronchopneumonia is typically ____focal and ___lateral.

A

Bronchopneumonia is typically multifocal and bilateral.

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5
Q

Which type of pneumonia is characterized by relatively mild upper respiratory symptoms?

A

Interstitial

(atypical)

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6
Q

Aspiration pneumonia is typically caused by which organisms?

(Give a few examples.)

A

Anaerobic bacteria

(e.g. Bacteroides, Fusobacterium, Peptococcus)

(from the oropharynx)

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7
Q

What is the most common cause of community-acquired pneumonia?

A

S. pneumoniae

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8
Q

What are the two most common causes of secondary pneumonia?

A
  1. S. pneumoniae
  2. S. aureus
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9
Q

Which causal organism associated with secondary pneumonia is often complicated by abcess and/or empyema formation?

A

S. aureus

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10
Q

What is a common cause of pneumonia in patients with cystic fibrosis?

A

Pseudomonas aeruginosa

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11
Q

Klebsiella pneumoniae is associated with pneumonia following what?

A

Aspiration of enteric flora

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12
Q

Name an organism associated with both secondary pneumonia and also pneumonia superimposed on COPD.

A

Haemophilus influenzae

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13
Q

Name two organisms associated with both community-acquired pneumonia and also pneumonia superimposed on COPD.

A

Moraxella catarrhalis;

Legionella pneumophila

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14
Q

What are the two most common causes of atypical pneumonia?

A
  1. Mycoplasma pneumoniae
  2. Chlamydia pneumoniae
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15
Q

What is the most common cause of atypical pneumonia in children?

A

RSV

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16
Q

What is a common cause of atypical pneumonia in immunosuppressed patients (e.g. in patients posttransplant)?

17
Q

S. aureus and H. influenzae are both associated with secondary pneumonia superimposed on pneumonia caused by what?

A

Influenzavirus

18
Q

Name a few common causes of bronchopneumonia.

A

H. influenzae;

S. aureus;

  • Legionella pneumonia*;
  • Moraxella catarrhalis*
19
Q

What is a zoonotic cause of atypical pneumonia associated with high fevers?

A

Coxiella burnetti

(‘Q fever’)

20
Q

Epiglottitis is most commonly caused by what?

A

H. influenzae

21
Q

Bronchitis is mostly of _______ etiology.

A

Bronchitis is mostly of viral etiology.

22
Q

Pneumonia is mostly of _______ etiology.

A

Pneumonia is mostly of bacterial etiology.

23
Q

Hospital-acquired pneumonia is almost always a(n) ________ (typical/atypical) ________ (bacterial/viral) pneumonia.

A

Hospital-acquired pneumonia is almost always a typical bacterial pneumonia.

24
Q

Ventilator-acquired pneumonias put one at risk for what two organisms in particular?

A

Legionella spp.;

Pseudomonas spp.

25
Which *Mycobacteria spp.* is associated with cytic fibrosis?
*M. abcessus*
26
What are the most common two non-TB *Mycobacteria spp.*?
*M. Kansasii*; MAC (if AIDS is suspected)
27
Which virus of the *Paramyxoviridae* family causes acute upper and lower respiratory tract infections in all age groups?
Human metapneumovirus
28
Which *Pseudomonas* virulence factor promotes adherence to respiratory epithelium and interferes with effective phagocytosis and antibody- or complement-mediated killing?
Alginate
29
Do *Pseudomonas spp.* form biofilms?
Yes.
30
Alginate expression in *Pseudomonas* is almost exclusively seen in patients with what diease?
Cystic fibrosis
31
Describe *M. catarrhalis* in terms of its microbiology.
(HIGH clinical significance) ## Footnote **Gram-negative diplococcus; oxidase-positive**
32
**True/False**. *M. catarrhalis* is highly penicillin-sensitive.
**True/False**. *M. catarrhalis* is ***often*** penicillin-***resistant***.
33
What pathogen is only very likely to be seen in a diabetic patient with pneumonia who recently traveled to SE Asia or Northern Australia?
*Burkholderia pseudomallei*
34
Which *Burkholderia spp.* can cause chronic, necrotizing pneumonia in CF patients?
*Burkholderia cepacian*