PTH/Vit. D Flashcards
intracellular Calcium is generally low or high?
low intracellular, high extracellulary
where is most calcium located?
in the bone
what is vitamin d’s main purpose?
to increase calcium reabsorption
where is vitamin d’s primary target?
the gut
what is the regulation of calcium linked with?
phosphate levels
calcium and phosphate are both required for
bone mineralization
osteoblasts do what?
bone formation
osteoclasts do what?
bone breakdown
estrogen promotes
osteoblasts
vitamine D and PTH both primarily act on
osteoblasts
high level of cortisol stimulate
osteoclasts
parathyroid hormonen is produced in
the parathyroid gland by chief cells
PTH stimulates calcium
reabsorption in the kidney
PTH promoters the conversion of
vitamin D to active form
calcitonin reduces
osteoclast activity
vitamin D regulates
calcium levels in the obdy
vitamin D stimulates calcium absorption form
the gut
direct action of PTH at the - kidneys
decreases excretion of calcium
increases excretion of phosphate
stimulates active form of vip D
direct action of PTH at the - bone
increases the number + activity of osteoclasts
indirect action of PTH at the - kidneys
increased calcium reabsorption in tubules
indirect action of PTH at the - bone
increase calcium reabsorption
where does Vit D primarily have it’s effect?
on the GI tract
vit D action at the bone is to promote
bone mineralization
vit d affects at the kidney is to act synergistically with PTH to promote
calcium reabsorption
rickets
deficiency of vitamin D in children
osteomalacia
deficiency of vitamin D in adults
osteoporosis major risk factor is
decline in estrogen levels in aging women
cushing’s disease can cause
osteoporosis
what can help osteoporosis?
weight baring activities
