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Central Nervous System > Psychosis and Schizophrenia > Flashcards

Psychosis and Schizophrenia Flashcards

1
Q

What are positive symptoms of Psychosis and Schizophrenia

A
  • Delusions
  • Hallucinations
  • Disorganisations
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2
Q

What are negative symptoms of Psychosis and Schizophrenia

A
  • Social withdrawal
  • Neglect
  • Poor Hygiene
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3
Q

What are the 4 types of 1st Generation Antipsychotics

A
  • Phenothiazines
  • Butyrophenomes
  • Thioxanthenes
  • Other (Pimozide, Sulpiride)
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4
Q

Examples of 1st Generation Antipsychotics: Phenothiazides

A

ending in…ZINE…

  • Chlorpromazine
  • Pericyazine
  • Prochlorperazine
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5
Q

Examples of 1st Generation Antipsychotics: Butyrophenones

A

ending in…IDOL…

  • Benperidol
  • Haloperidol
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6
Q

Examples of 1st Generation Antipsychotics: Thioxanthenes

A

ending in…IXOL…

  • Flupentixol
  • Zuclopenthixol
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7
Q

Examples of 1st Generation Antipsychotics: Other

A

ending in…IDE…

  • Pimozide
  • Sulpiride
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8
Q

Which 1st Generation Antipsychotics are the most sedating

A
  • (Group 1) Phenothiazides
    Chlorpromazine
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9
Q

Which 1st Generation Antipsychotics are the least sedating

A

Other
- Pimozide
- Sulpiride

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10
Q

Which 1st Generation Antipsychotics have the most EPSE

A
  • (Group 3) Phenothiazides
    Prochlorperazine
  • Butyrophenones
    Haloperidol
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11
Q

Which 1st Generation Antipsychotics have the least EPSE

A
  • (Group 2) Phenothiazides
    Pericyazine
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12
Q

Which 1st Generation Antipsychotics have antimuscarinic effects

A
  • Other
    Pimozide
  • Thioxanthenes
    Flupentixol
  • (Group 1) Phenothiazides
    Chlorpromazine
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13
Q

Examples of 2nd Generation Antipsychotics (atypical)

A
  • Aripiprazole
  • Clozapine
  • Olanzapine
  • Quetiapine
  • Risperidone
  • Amisulpride
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14
Q

Which Antipsychotic has the lowest Hyperprolactinaemia (prolactin in blood)

A

Aripirazole

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15
Q

Which Antipsychotics cause hypotension

A
  • Clozapine
  • Quetiapine
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16
Q

Which Antipsychotics cause Hyperglycaemia (basically most 2nd gen)

A
  • Clozapine
  • Risperidone
  • Olanzapine
  • Quetiapine
17
Q

Which Antipsychotics induce weight gain

A
  • Clozapine
  • Olanzapine
18
Q

What side effect do all Antipsychotics cause

A

sexual dysfunction

19
Q

Which Antipsychotics is QT prolongation the most common

A
  • Haloperidol
  • Primozide
20
Q

Which Antipsychotic has the highest risk of gambling

A

Aripiprazole

21
Q

What monitoring is need for Antipsychotics

A
  • weight
  • Fasting HBA1c
  • ECG
  • Blood Pressure
  • Full blood count
  • LFT
  • U and E
22
Q

When would you initiate Clozapine

A

Resistant Schizophrenia

  • tried 2+ antipsychotics for 6 to 8 weeks
  • 1 of those needs to be a 2st generation
23
Q

What should happen if patient misses more than 2 doses of Clozapine

A

Specialist re-initiation

24
Q

How long are Leucocyte and Neutrophils monitored in Clozapine

A

weekly for 18 weeks
==> every 2 weeks till 1 year
====> monthly (also 1 month after last dose)

25
Q

Why should anyone on Clozapine report tachycardia

A

as side effects of Clozapine is…

  • Myocarditis (inflammation of heart muscles)
  • Cardiomyopathy (reduced pumping ability)
26
Q

Why should anyone on Clozapine report and stop on constipation

A

as a side effect of Clozapine is…

  • GI disturbances
    ===> can cause intestinal block
27
Q

What is used to ease patient adherence for antipsychotic drugs

A

Depot Injection

Central Nervous System (14 decks)

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