Psychosis and Schizophrenia Flashcards
What are positive symptoms of Psychosis and Schizophrenia
- Delusions
- Hallucinations
- Disorganisations
What are negative symptoms of Psychosis and Schizophrenia
- Social withdrawal
- Neglect
- Poor Hygiene
What are the 4 types of 1st Generation Antipsychotics
- Phenothiazines
- Butyrophenomes
- Thioxanthenes
- Other (Pimozide, Sulpiride)
Examples of 1st Generation Antipsychotics: Phenothiazides
ending in…ZINE…
- Chlorpromazine
- Pericyazine
- Prochlorperazine
Examples of 1st Generation Antipsychotics: Butyrophenones
ending in…IDOL…
- Benperidol
- Haloperidol
Examples of 1st Generation Antipsychotics: Thioxanthenes
ending in…IXOL…
- Flupentixol
- Zuclopenthixol
Examples of 1st Generation Antipsychotics: Other
ending in…IDE…
- Pimozide
- Sulpiride
Which 1st Generation Antipsychotics are the most sedating
- (Group 1) Phenothiazides
Chlorpromazine
Which 1st Generation Antipsychotics are the least sedating
Other
- Pimozide
- Sulpiride
Which 1st Generation Antipsychotics have the most EPSE
- (Group 3) Phenothiazides
Prochlorperazine - Butyrophenones
Haloperidol
Which 1st Generation Antipsychotics have the least EPSE
- (Group 2) Phenothiazides
Pericyazine
Which 1st Generation Antipsychotics have antimuscarinic effects
- Other
Pimozide - Thioxanthenes
Flupentixol - (Group 1) Phenothiazides
Chlorpromazine
Examples of 2nd Generation Antipsychotics (atypical)
- Aripiprazole
- Clozapine
- Olanzapine
- Quetiapine
- Risperidone
- Amisulpride
Which Antipsychotic has the lowest Hyperprolactinaemia (prolactin in blood)
Aripirazole
Which Antipsychotics cause hypotension
- Clozapine
- Quetiapine
Which Antipsychotics cause Hyperglycaemia (basically most 2nd gen)
- Clozapine
- Risperidone
- Olanzapine
- Quetiapine
Which Antipsychotics induce weight gain
- Clozapine
- Olanzapine
What side effect do all Antipsychotics cause
sexual dysfunction
Which Antipsychotics is QT prolongation the most common
- Haloperidol
- Primozide
Which Antipsychotic has the highest risk of gambling
Aripiprazole
What monitoring is need for Antipsychotics
- weight
- Fasting HBA1c
- ECG
- Blood Pressure
- Full blood count
- LFT
- U and E
When would you initiate Clozapine
Resistant Schizophrenia
- tried 2+ antipsychotics for 6 to 8 weeks
- 1 of those needs to be a 2st generation
What should happen if patient misses more than 2 doses of Clozapine
Specialist re-initiation
How long are Leucocyte and Neutrophils monitored in Clozapine
weekly for 18 weeks
==> every 2 weeks till 1 year
====> monthly (also 1 month after last dose)
Why should anyone on Clozapine report tachycardia
as side effects of Clozapine is…
- Myocarditis (inflammation of heart muscles)
- Cardiomyopathy (reduced pumping ability)
Why should anyone on Clozapine report and stop on constipation
as a side effect of Clozapine is…
- GI disturbances
===> can cause intestinal block
What is used to ease patient adherence for antipsychotic drugs
Depot Injection
