Parkinson's Disease and its Medications Flashcards
What is the treatment of Parkinson’s disease if patients motor symptoms are affecting the quality of life of the patient
Levodopa + Carbidopa/Bensecazide
(co-cardopa) (co-benaldopa)
What is the treatment of Parkinson’s disease if patients motor symptoms are not affecting the quality of life of the patient
1st: Levodopa (co)
2nd: Non-ergot-derived dopamine receptor
3rd: Monoamine Oxidase B Inhibitors
Why is Levodopa usually given with Carbidopa or Bensecazide
To prevent premature breakdown of levodopa into dopamine before moving though the BBB
What are the Side effects of Levodopa
- Gambling
- Binging
- Hypersexuality
- Sudden onset of sleep
- red urine
How to treat the sudden onset of sleep caused by Levodopa
Modafinil
What are examples of Non-Ergot Derived Dopamine Receptor
- Pramipexol
- Ropinerole
- Rotigotine
What are side effects of Non-Ergot Derived Dopamine Receptor
- impulse disorders (like levodopa_
- sudden onset of sleep
- Hypotension
What are examples of Monoamine Oxidase B Inhibitors
- Rasagiline
- Selegiline
Which drug when given with Monoamine Oxidase B Inhibitors can cause hypertensive crisis
Phenylephrine
What to add to levodopa as dual therapy is patients develop dyskinesia (involuntary movement)
- Non-Ergot Derived Dopamine Receptor
- Ergot Derived Dopamine Receptor
- Monoamine Oxidase B Inhibitors
- COMT Inhibitor
Examples of COMT Inhibitors
- Entacapone
- Telcapone
What colour does entacapone change your urine
red/brown
Which patient group do you avoid COMT Inhibitors in
Cardiovascular Disease
What are examples of Ergot Derived Dopamine Receptor
- Bromocriptine
- Cabergoline
What are the side effects of Ergot Derived Dopamine Receptor
- Pulmonary Reactions
- Pericardial reactions
