Parkinson's Disease and its Medications Flashcards
What is the treatment of Parkinson’s disease if patients motor symptoms are affecting the quality of life of the patient
Levodopa + Carbidopa/Bensecazide
(co-cardopa) (co-benaldopa)
What is the treatment of Parkinson’s disease if patients motor symptoms are not affecting the quality of life of the patient
1st: Levodopa (co)
2nd: Non-ergot-derived dopamine receptor
3rd: Monoamine Oxidase B Inhibitors
Why is Levodopa usually given with Carbidopa or Bensecazide
To prevent premature breakdown of levodopa into dopamine before moving though the BBB
What are the Side effects of Levodopa
- Gambling
- Binging
- Hypersexuality
- Sudden onset of sleep
- red urine
How to treat the sudden onset of sleep caused by Levodopa
Modafinil
What are examples of Non-Ergot Derived Dopamine Receptor
- Pramipexol
- Ropinerole
- Rotigotine
What are side effects of Non-Ergot Derived Dopamine Receptor
- impulse disorders (like levodopa_
- sudden onset of sleep
- Hypotension
What are examples of Monoamine Oxidase B Inhibitors
- Rasagiline
- Selegiline
Which drug when given with Monoamine Oxidase B Inhibitors can cause hypertensive crisis
Phenylephrine
What to add to levodopa as dual therapy is patients develop dyskinesia (involuntary movement)
- Non-Ergot Derived Dopamine Receptor
- Ergot Derived Dopamine Receptor
- Monoamine Oxidase B Inhibitors
- COMT Inhibitor
Examples of COMT Inhibitors
- Entacapone
- Telcapone
What colour does entacapone change your urine
red/brown
Which patient group do you avoid COMT Inhibitors in
Cardiovascular Disease
What are examples of Ergot Derived Dopamine Receptor
- Bromocriptine
- Cabergoline
What are the side effects of Ergot Derived Dopamine Receptor
- Pulmonary Reactions
- Pericardial reactions
How should you withdraw Parkinson’s medications
not abruptly
How should you stop ‘off period’ affecting the patient with parkinson’s medication
use MR preparations
How to treat hypotension derived form parkinson’s medication
Midodrine
