Psychiatric Disorders and Substance Abuse in Pregnancy Flashcards
what are the principles of Tx of psychiatric disorders in pregnancy
Drugs with low risk to both mother and fetus
Lowest dose monotherapy (avoid depot)
Increase screening of fetus- cardio and growth
Encourage breastfeeding whenever possible
what drug used in anxiety disorders should be avoided in pregnancy and why
benzodiazepams
causes cleft palate, and neonatal withdrawal
what side effects can anticonvulsants [used as mood stabilisers] cause = valproate
Neural tube defects craniofacial defects CV abnormalities IUGR reduced IQ cleft palate genitourinary anomalies
what side effects can anticonvulsants [used as mood stabilisers] cause = carbamazepine
facial dysmorphism
cardiac anomalies
fingernail hypoplasia
Neural Tube Defects
vitamin K deficiency»_space; haemorrhagic disease of newborn
what side effects can anticonvulsants [used as mood stabilisers] cause = lamotrigine
Steven Johnson syndrome to baby if breast fed
what side effects can Lithium [used as mood stabilisers] cause
Cardiac abnormalities
risk maternal toxicity
Ebstein’s anomaly [congenital heart defect]
Neonatal hypotonia, hypothyroidism, hypoglycaemia
what is lithium contraindicated in
breast feeding
are antipsychotics considered safe in pregnancy
yes
what side effects do typical antipsychotics have
gest diabetes, IUGR
what drugs in the Tx of schizophrenia should not be used in pregnancy
Anticholinergic drugs [used to Tx extrapyramidal side effects]
what atypical antipsychotic is consider contra indicated in breast feeding
clozapine
what drug is associated with an increased risk of inducing extrapyramidal reactions in breast fed babies
olanzapine
what TCA and SSRI can be used in breast feeding mothers
sertraline
amitriptilline
when is the onset of post natal depression
2-6 weeks postnatal
Sx of postnatal depression
Tearfulness, irritable, anxiety, lack of enjoyment and poor sleep, weight loss
