Psych Part 2 Flashcards
Biological Basis of Schizophrenia
If one twin has schizophrenia, other twin has 50% likelihood.
Stress-diathesis theory - genetics is the basis but stress required for onset.
Dopamine hypothesis: dopamine pathway is hyperactive. Potentially overabundance and activity of receptor. Dopamine antagonists are sometimes successful. Positive Symptoms. Maybe hyperactivation of temporal lobes as well.
Maybe hypoactivation of frontal lobes. Negative symptoms.
Biological Basis of Depression
Genetics; links to dopamine, serotonin, and norepinephrine.
Often accompanies other brain disorders: Parkinsons, Brain trauma
Neurodevelopmental Disorders
Arise in utero or shortly after.
Down Syndrome (Trisimony 21)
ADHD - understimulation in regions of the brain
ASD - hypothesis that is under-formation of mirror neurons.
Neurocognitive Disorders
General term - dementia. A severe loss of cognition beyond normal aging trajectory.
Alzheimers - most common, 50% of people over 90 will have.
Parkinsons
Alzheimers
Anterograde amnesia - no new memories.
Retrograde amnesia - stepwise, so loss of most recent memories first.
Includes visual memory.
Cortical disease resulting from neural plaques (beta-amyloid protein and neurofibrillary triangles [tau protein]). May cause cell death by impeding cell nutrient/waste transport. There is some evidence of loss of ACh function in the hippocampus.
Parkinsons
A movement disorder, loss of dompaminergic neurons in the basal ganglia and substantia nigra.
Symptoms: resting tremor; slow movement; rigidity; shuffle; 50-80% develop dementia.
L-dupa; can cross the blood brain barrier and has some positive effect.
3 types of stressors
Catastrophe, life changes, daily hassles
Prolonged stress
immunosuppression; infertility; hypertension
Response to Stressors
Physiological - sympathetic nervous system
Cognitive - hypothalamus releases corticotropin releasing hormone (CRH) –> pituitary releases adrenocorticotropic hormone (ACTH) –> Adrenal glands releases Cortisol (glucocorticoid) –> causes shift from glucose energy to fat, but keeps blood glucose high as this is essential for brain.
Nonassociative learning
Repeated Exposure to a stimulus
Habituation - tuning out a stimulus. Dishabituation is the reverse process.
Sensitization - Increased responsiveness to repeated stimulus or particularly noxious stimulus. Does not usually result in long term change.
Associative Learning
Classical
Operant
Timing is essential for both these modes of learning.
Classical Conditioning
Two stimuli are paired so that the response to one stimuli changes.
Neutral stimulus - does not elicit an intrinsic response.
Unconditioned response - elicits unconditioned response
Conditioned stimulus - originally neutral
Conditioned response - learned response to conditioned stimulus
Process for developing/maintaining conditioned responses (Classical or Operant)
Acquisition
Extinction
Spontaneous recovery
Generalization
Discrimination
Note that we are highly predisposed to adaptive associations. Ex. Taste-aversion.
Operant (instrumental) conditioning
Punishment + reward –> new behaviour
Punishment pathways are largely mediated by the amygdala.
Reward pathways are largely mediated by the hippocampus.
B. F. Skinner
Rat in a box experiment. Push lever for food, push lever to end electric shock.
Reinforcement
Anything in operant conditioning that increases the likelihood of a behaviour.
Can be positive (addition of good)
Can be negative (removal of bad)
Primary reinforcement - innately satisfying
Secondary reinforcement - Learned reinforcers that must be paired with primary reinforcement to generate learned behaviour.
Reinforcement Schedule
Required in Operant Conditioning.
Continuous: rapid acquisition and rapid extinction. Best method to teach a new behaviour.
Intermittent: Longer acquisition period, longer retention
4 important intermittent reinforcement schedules
A fixed ratio - reinforcement after a set number of instances of behaviour. Produces a high response rate, more behaviour = more reward.
A variable ratio - reinforcement at variable number of instances of behaviour. Slowest rate of extinction.
A fixed interval - reinforcement after a set amount of time
A variable interval - reinforcement at irregular intervals
Punishment in Operant Conditioning
Decreases behaviour.
Punishment can be positive or negative.
Positive - present undesirable stimulus
Negative - removal of desirable stimulus
Punishment is less effective than reward. Typically if punishment stops behaviour will too.
Rewards are more specific than punishment. The former says what to do. The later says what not to do - much broader!