PSYCH - Panic, Anxiety, Mood Disorders Flashcards
Define mood disorders
disorders in which extreme variatons in mood (either high or low) are the primal feature
in most cases, these variations are maladaptive
Mood disorders can be broken into two moods which are:
mania
depression
*note: these typically occur separately but sometimes can occur simultaneously and create rapidly alternating moods
Define: Mania
intense and unrealistic feelings of excitement and euphoria
Define: Depression
feelings of extraordinary sadness and dejection
Unipolar vs Bipolar disorders
Unipolar: where a person only experiences depressive episodes
Bipolar: where a person experiences both depressive and manic episodes
Manic episode (and criteria/symptoms)
- markedly elevated, euphoric or expansive mood, usually with intermittent bursts of intense irritability or sometimes violence
- Must persist for >1 week and show 3 or more additional symptoms in the same time period
- Inflated self-esteem or feelings of grandeur
- Decreased need for sleep
- More talkative than normal, feels pressure to keep talking
- Racing thoughts/ideas
- Distracted
- Increase in goal directed activity (work, sex, socially) or psychomotor agitation
- Excessive involvement in high risk activities (sexual indiscretions, spending large amounts of money, etc.) - due to inability to see future consequences
What is the most common form of mood episode that people present with?
Major depressive episode
Major depressive episode (and criteria)
- markedly depressed for majority of the day, most days, for >2 weeks
- must exhibit at least 3 or 4 other symptoms (or 5?) (different than normal functioning)
- One symptom must include depressed mood or loss of pleasure
- Depressed mood
- Diminished interest in pleasure in activities
- Decreased ability to think, concentrate
- Feelings of worthlessness or inappropriate/excessive feelings of guilt
- Recurrent thoughts of death, suicide
- Insomnia or hypersomnia
- Psychomotor agitation or retardation
- Significant weight loss or gain
- Fatigue
- Cause clinically ++distress
If a patient experiences a major depressive episode or a manic episode but not both, do they meet the criteria for mixed episode?
no
Signs and symptoms of a manic episode can cause disturbances that can result in what negative impacts?
- social or occupational activities
- require hospitalization to prevent harm to self, others
- psychotic features
Major mood disorders occur ______x more frequently than schizophrenia.
_____________ is the most common form, and rates are (higher/lower) in women than men.
15-20x
Unipolar major depression
higher in women than men (2:1)
Lifetime risk of developing bipolar disorder is ______%
Is there any difference between sexes?
0.4-2.2% (2006)
no discernable difference between sexes (not a genetic trait, may have predispositions x environmental factors)
What types of depression aren’t considered mood disorders?
- depression that results from recent stress
- dealing with death, grieving
- postpartum depression
What are specifiers?
different patterns of symptoms or features
Specifiers of Major Depression
1) Atypical symptoms:
- Leaden paralysis (heavy feelings in arms or legs)
- Acutely sensitive to interpersonal rejection for long periods
- Brightens to positive events
- More often female than male, respond better to monoamine oxidase inhibitors (MAOI)
2) Melancholic symptoms:
- early morning awakenings
- depressed more in the morning
- more often connected to genetic factors
3) Psychotic symtpoms:
- Mood-congruent delusions or hallucinations
- Tx usually requires antipsychotic meds in addition to antidepressants
- Poorer LT prognosis
Biological Factors that contribute to Unipolar Mood Disorders
Genetic influences:
- prevalence 3x higher among blood relatives w/ Dx than general population
- Monozygotic twins with one twin who meets diagnosis is 2x more likely than dizygotic twins
- Sx such as depressed mood do not appear to be heritable, but symptoms such as loss of libido and/or appetite do
- UMD occurred 7x more often in biological relatives of severely depressed adoptees than control
- Gene-environmental interaction
Neurochemical: increases in NE activity, very little understood
Hormone Regulatory Systems: increased cortisol levels (feedback loop from HPA axis), failure of feedback mechanisms, thyroid irregularities (hypothyroidism common in depressed people)
Neurophysiological & neuroanatomical: stroke studies
Sleep and Biological Rhythms
Psychosocial factors that contribute to Unipolar Mood Disorders
1) Stressful life events
2) Diathesis-stress models: Personality and cognitive predispositions, early adversity and parental loss
3) Psychodynamic: Threats to self-esteem and developmental needs
4) Behavioural
- Depression resulting from either negative reinforcement increases or positive reinforcement decreases
- Not typically very reliable
5) Interpersonal Effects: Lack of social support; Marriage and family life
Differences in sex in regard to unipolar mood disorders
Women:
- 2x as likely to develop unipolar mood disorders than men
- Rumination more prominent in women
- Women statistically have more “negative” interpersonal events
- Evidence that development of secondary sex characteristics harder psychologically for females than males
Men:
- Among school children, boys equally or more likely to be diagnosed
- Men statistically engage in “distracting” activities
Both/neither
- Few exceptions in developing countries such as Nigeria and Iran
- In North America, these differences start in adolescence and continue ~65
- Hormonal factors not very reliable
- Sex differences in neuroticism
- Social factors
Bipolar disorders are distinguished from unipolar disorders by the presence of __________ or __________ symptoms.
manic, hypomanic
Hypomanic
person experiences abnormally elevated, expansive or irritable mood for at least 4 days
- similar symptoms as mania, but to a lesser degree
- less impairment on social, occupational function
- hospitalization not required
Cyclothymic disorder (and symptoms between depressive and hypomanic episode)
Cyclothymic disorder: cyclical mood changes less severe than bipolar. Ppl do not experience delusions and do not show marked impairment caused by manic or major depressive episodes
Cyclothymic depressive episode: dejected, distinct loss of pleasure in activities, low energy, social withdrawal, feelings of inadequacy
Cyclothymic hypomanic episode: spark in creativity and production, increased mental and physical energy
Define:
Bipolar I disorder
Mixed episodes
distinguish from MDD by at least one episode of mania or mixed episode
mixed episode: sx of both full blown manic and major depressive episodes for at >1 week. These can be intermixed or rapidly alternating
Bipolar II
person does not experience full-blown manic episodes but does experience hypomanic episodes and major depressive episode
- more common than Bipolar I
Prevalence/Risks in developing Bipolar I and II
- combined ~3% of population will have either
- equal occurrence in men and woman
- most will experience periods of remission, relatively Sx free
- 20-30% experience significant occupational/interpersonal impairment
- ~60% have chronic occupational/interpersonal impairment between episodes
- ~10-13% of people who have initial major depressive episode will later have manic or hypomanic episode
Causal Factors in Bipolar Disorder
Biological: genetic influences, neurochemical, other brain and thyroid abnormalities
Psychosocial factors: stressful life events, others
Cultural variations
Biological Causal factors of Bipolar Disorder
Genetic influences
- 8-9% of first-degree relatives of those who have bipolar disorder can be expected to receive a diagnosis (~1% in gen. pop.)
- Concordance rates for monozygotic twins (~60%) significantly higher than dizygotic(~12%)
- Genes account for 80-90% variance in the likelihood to develop bipolar disorder
Biological Causal factors of Bipolar Disorder
Neurochemical
- Evidence suggests that increased dopamine activity is linked to manic symptoms, particularly hyperactivity, grandiosity, and euphoria
- Possible that sodium ions have difficulty being transported across neural membranes (evidenced by role of Lithium in tx)
Biological Causal factors of Bipolar Disorder
Other
- Abnormalities in thyroid function
- Shifting patterns in brain activity and blood flow
- Basal ganglia and amygdala enlarged in bipolar disorder
- Increased activation in emotional processing areas of the brain
Psychosocial factors for Bipolar Disorders
- Stressful life events: important in predisposition
-
Other:
- low social support
- personality and cognitive variables
- striving and increased sensitivity to reward in the environment predicts increases in manic symptoms
- pessimistic attributional style (someone who is always negative)
Cultural Variations in unipolar and bipolar mood disorders
- Western countries see higher rates of depression
- Non-Western countries have more somatic manifestations of depression, vs more psychological manifestations in Western countries
- Cultural beliefs about autonomy and independence (more common in Western cultures) attributed to greater psychological (internal) manifestations
- Some cultures show signs of outwards transgression towards others instead of feelings of guilt or self-deprecation
- Very little is understood about the prevalence discrepancies between countries
- In Canada, depression higher among Aboriginals
- Research indicates rates of unipolar depression are inversely proportional to socioeconomic status
- Research indicates that bipolar disorder is more directly proportional to socioeconomic status
Treatment options and recovery time in mood disorders
- Majority of patients will recover without treatment (often only temporarily) within <1 year
- more than half of people with mood disorders receive inadequate or no treatment at all
- Types of treatment:
- Meds (antidepressants, antipsychotics)
- Lithium and other mood-stabilizers (anti-manic and anti-depressant effects)
- Electroconvulsive therapy (usually for immediate & serious suicidal risk)
- Transcranial Magnetic Stimulation (brief, intense magnetic fields that induce electrical activity in certain parts of the brain)
- CBT & BA
- Interpersonal Therapy (not widely available)
- Family and Marital Therapy
Definition of suicide
The act of taking one’s own life