Psoriasis Flashcards
what is typical location of psoriasis ?
- Elbow, knee, gluteal cleft and scalp.
Types of psoriasis ?
- Type I disease (HLA-Cw6+) ( more severe ) have an earlier onset, more widespread disease and frequent recurrences. and it involves genital region. usually after infections.
- Type II psoriasis.
what is the characteristic lesion for psoriasis?
- Plaques, papule.
- The characteristic lesion is a sharply demarcated erythematous plaque with scale; the plaques may be localized or widespread in distribution.
Which features are estimated in PASI score ?
Erythema, induration and scale.
What is the most common cause of erythroderma is adults ?
Psoriasis.
When can we use systemic treatment PSORIASIS AREA AND SEVERITY INDEX (PASI)?
- over 10.
- max. 72
What is the least common classification of psoriatic arthritis?
Arthritis mutilans
DOC in the treatment of pustular psoriasis ?
Acitretin.
SUBTYPES OF PSORIASIS ?
- psoriasis guttata
- psoriatic erythrodermia
- palmoplantar psoriasis.
- pustular psoriasis
- pustulosis of the hand and soles.
- psoriatic arthritis.
- inverse psoriasis.
- nail psoriasis.
- scalp psoriasis.
KOEBNER PHENOMENON is ?
After skin injury typical psoriatic leasions are seen in affected skin.
Immunopathogenesis of psoriasis ?
- prominent involvement of helper T-cell subsets (Th1 and Th17) and their secreted cytokines: TNF - alpha, IL12 , IL 23.
Most common presentation of psoriatic arthritis ?
- Mono and asymmetric oligoarthritis. (involvement of PIP and DIP) “ sausage digit “
- In contrast to RA its MCP joints
Treatment of psoriasis ?
- Topical : coricosteriods, vit D3 analogue, retinoids and acetylic acid.
- Systemic: retinoids, methotrexate and cyclosporine.
- BIOLOGIC THERAPY
What is the peak age of onset of psoriasis ?
Two peaks. one at 20–30 years of age and a second peak at 50–60 years.
classification of psoriatic arthritis called?
moll and wright classification
Name the biological treatments of Psoriasis ?
- Infliximab. (TNF-alpha)
- Etanercept. (TNF-alpha)
- Adalimab. (TNF-alpha)
- Ustekinumab. ( IL 12/23)
Which drug would u recommend to a patient with hypertension and severe psoriasis ?
Methotrexate.
PASI score in severe psoriasis is :
- More than 20.
- and u can use systemic TTT when more than 10
Wax candle sign is ?
If the superficial silvery white scales are removed via curettage (grattage method), a characteristic coherence is observed, as if one has scratched on a wax candle (“signe de la tache de bougie”).
Psoriasis, definition ?
is a chronic, immune-mediated dermatosis that results from a polygenic predisposition combined with environmental triggers.
Which subtype of psoriasis is induced by rapid taper of systemic corticosteroids?
- Pustular psoriasis (von Zumbusch) as well as flares of plaque psoriasis.
Which clinical feature is the most common characteristic for psoriatic arthritis ?
Asymmetry of joints involvement.
SPECIFIC PSORIASIS SIGNS ?
- Wax candle sign.
- Auspitz sign.
- Köbner phenomenon.
When do we use the term “inverse” psoriasis ?
When flexural areas are the only sites of involvement.
