Autoimmune diseases ( Scleroderma and dermatomyositis ) Flashcards

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1
Q

What is the typical sign for dermatomyositis?

A

Gottron’s sign

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2
Q

What is the hallmark antibodies for MCTD ?

A

• anti–U1-RNP antibodies.

#_Symptoms:
• Raynaud phenomenon, swollen hands.
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3
Q

TTT of raynaud’s syndrome ?

A
  • CCB.
  • Nitoglycerin.
  • Sildenfil (viagra)
  • parental vasodilators.
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4
Q

Scleroderma?

A
  • An autoimmune systemic disease occurring with the fibrosis of the skin and internal organs.
  • more common in women 9 : 1 - onset: 20-40 years
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5
Q

Diagnostic Criteria for dermatomyositis ?

A

_Bohan and Peter Criteria:

1• Symmetric proximal muscle weakness “ most common symptom “
2• typical rash
3• elevated serum muscle enzymes
4•myopathic changes on EMG
5• characteristic muscle biopsy abnormalities and
absence of histopathologic signs of other
myopathies

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6
Q

dermatomyositis complications ?

A
  • Interstitial lung diseases.
  • Esophageal diseases.
  • Myocarditis.
  • Malignancy.
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7
Q

Which immunological marker in systemic sclerosis is an indicator of severe course (dSSc) ?

A

Anti-DNA Topoisomerase I antibodies (Scl 70)

  • Anti-centremere is associated with less severe course. (ISSc)
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8
Q

Dermatomyositis TTT?

A

GCS are the cornerstone of initial therapy.

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9
Q

what basic laboratory studies can be performed to confirm the diagnosis of systemic sclerosis?

A
  • ANA ( ACA for limited and Scl-70 for diffuse )
  • lung vital capacity and diffusing capacity for carbon monoxide.
  • HRCT.
  • Intrarenal duplex doppler sonography.
  • ECHO.
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10
Q

What are the potential complications of this morphea ?

A
  • Joint immobility.
  • difficulty breathing.
  • hemiatrophia faciei.
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11
Q

Which ANA is characteristic for systemic sclerosis ?

A

Scl-70 ANA.

*the question is not specific enough.

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12
Q

Which immunological marker in systemic sclerosis is most commonly in dSSc with renal involvement ?

A

Anti-RNA polymerase-III antibodies

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13
Q

Which syndromes are overlapping when u have “ Anti-U1RNP antibodies “ ?

A

The marker of MCTD

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14
Q

Criteria for the Classification of Systemic Sclerosis?

A
  • Skin hardening on the hands (9 points)
  • Sclerodactyly (2-4)
  • Erosive lesions/ulceration of fingers (2-3)
  • Telangiectasia (2)
  • Abnormal capillaroscopy (2)
  • Pulmonary fibrosis / PAH (2)
  • Raynaud’s phenomenon (3)
  • SSc immunological markers (3)

≥9

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15
Q

Indicate specific autoantibodies that can occur in dermatomyositis ?

A
  • Jo-1
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16
Q

What is the most specific rash for DM ?

A
  • Heliotrope rash.
    • A reddish-purple eruption on the upper eyelid
    • accompanied by swelling of the eyelid
17
Q

Which syndromes are overlapping when u have “Anti-PM-Scl “ antibodies ?

A
  • systemic sclerosis overlap syndromes with scleromyositis.