Autoimmune diseases ( Scleroderma and dermatomyositis ) Flashcards
What is the typical sign for dermatomyositis?
Gottron’s sign
What is the hallmark antibodies for MCTD ?
• anti–U1-RNP antibodies.
#_Symptoms: • Raynaud phenomenon, swollen hands.
TTT of raynaud’s syndrome ?
- CCB.
- Nitoglycerin.
- Sildenfil (viagra)
- parental vasodilators.
Scleroderma?
- An autoimmune systemic disease occurring with the fibrosis of the skin and internal organs.
- more common in women 9 : 1 - onset: 20-40 years
Diagnostic Criteria for dermatomyositis ?
_Bohan and Peter Criteria:
1• Symmetric proximal muscle weakness “ most common symptom “
2• typical rash
3• elevated serum muscle enzymes
4•myopathic changes on EMG
5• characteristic muscle biopsy abnormalities and
absence of histopathologic signs of other
myopathies
dermatomyositis complications ?
- Interstitial lung diseases.
- Esophageal diseases.
- Myocarditis.
- Malignancy.
Which immunological marker in systemic sclerosis is an indicator of severe course (dSSc) ?
Anti-DNA Topoisomerase I antibodies (Scl 70)
- Anti-centremere is associated with less severe course. (ISSc)
Dermatomyositis TTT?
GCS are the cornerstone of initial therapy.
what basic laboratory studies can be performed to confirm the diagnosis of systemic sclerosis?
- ANA ( ACA for limited and Scl-70 for diffuse )
- lung vital capacity and diffusing capacity for carbon monoxide.
- HRCT.
- Intrarenal duplex doppler sonography.
- ECHO.
What are the potential complications of this morphea ?
- Joint immobility.
- difficulty breathing.
- hemiatrophia faciei.
Which ANA is characteristic for systemic sclerosis ?
Scl-70 ANA.
*the question is not specific enough.
Which immunological marker in systemic sclerosis is most commonly in dSSc with renal involvement ?
Anti-RNA polymerase-III antibodies
Which syndromes are overlapping when u have “ Anti-U1RNP antibodies “ ?
The marker of MCTD
Criteria for the Classification of Systemic Sclerosis?
- Skin hardening on the hands (9 points)
- Sclerodactyly (2-4)
- Erosive lesions/ulceration of fingers (2-3)
- Telangiectasia (2)
- Abnormal capillaroscopy (2)
- Pulmonary fibrosis / PAH (2)
- Raynaud’s phenomenon (3)
- SSc immunological markers (3)
≥9
Indicate specific autoantibodies that can occur in dermatomyositis ?
- Jo-1