Bullous diseases Flashcards

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1
Q

Dermatitis Herpetiformis (DH) definition ?

A

Intensely itchy, chronic papulovesicular eruption distributed symmetrically
on extensor surfaces.

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2
Q

Typical for pemphigus foliacus in direct immunoflurescence ?

A

Presence of IgG antibodies anti-desmglein 1

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3
Q

Diagnosis of Dermatitis Herpetiformis ?

A
  • Skin biopsy ; collections of neutrophils (microabscesses).

- DIF ; Granular IgA deposits in normal-appearing skin are diagnostic for DH.

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4
Q

The gold standard of diagnosis of autoimmune bulllous diseases ?

A

Direct immunofluorescence

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5
Q

Common complication of Pemphigus vulgaris ?

A
  • secondary infection.

- disturbances of fluid and electrocyte.

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6
Q

In which bullous disease we can see Acantholysis ? and explain it ?

A

Is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes (in other words the keratinocytes detach from their neighbours and float free in the blisters).
- Seen in diseases such as pemphigus vulgaris.

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7
Q

Typical for dermatitis herpetiformis in direct immunoflurescence ?

A

Granular IgA in the dermal papillae. (even in normal-appearing skin)

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8
Q

Paraneaoplastic pemphigus (PNP) combines features of what diseases?

A
  • PNP lesions combine features of Pemighus V and erythema multiforme, clinically and histologically.
  • mucus membrane primarily and most severely involved.
  • associated with internal malignancy.
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9
Q

Typical for pemphigoid in direct immunoflurescence ?

A

IgG at the basement membrane zone (lamina lucida). and also C3.

  • IgG binds to two main antigens, most commonly to BP230 and BP180
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10
Q

What is may be required in case of blisters in children ?

A

Electron microscopy.

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11
Q

Most, if not all, DH patients have an associated with which condition ?

A

gluten-sensitive enteropathy

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12
Q

Which Drugs can induce PV ?

A

most significantly in association
with PV are;

  • Penicillamine
  • captopril
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13
Q

The biopsy for DIF in vesiculo-bullous diseases should be taken from ?

A

Peri-lesional skin.

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14
Q

PEMPHIGUS ?

A

A serious, acute or chronic, bullous autoimmune disease of SKIN and MUCOUS MEMBRANES based on acantholysis.
- Common in the middle age groups(40-60 years
of life).

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15
Q

What is the 1st line treatment for dermatitis herpetiformis ?

A
  • Dapsone.

- 2nd -> glucocoticosteriods.

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16
Q

Where does the pemphigus starts for most of the patients ?

A
  • Oral mucosa.