Psoriasis Flashcards

1
Q

Appearance of psoriasis

A

sharply demarcated erythematous plaque with micaceous scale

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2
Q

How is psoriasis a systemic disease?

A

psoriatic arthritis
psychosocial
metabolic syndrome - CVS

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3
Q

Cause of psoriasis

A

polygenic - HLA

environmental triggers

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4
Q

Environmental triggers for psoriasis

A

infections
drugs
trauma
sunlight

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5
Q

How are dermal dendritic cells activated?

A

interleukins, TNF alpha

stressed keratinocytes

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6
Q

Pathogenesis of psoriasis

A

DDC present to naïve T cells

Th cells –> plaque formation

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7
Q

What happens to the cell cycle in psoriasis?

A

decreased from 28 days to 3-5 days

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8
Q

When are neutrophils found in psoriasis?

A

active, pustular disease

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9
Q

Histology of psoriasis

A

hyperkeratosis
neutrophils in corneum
dilated capillaries
T cell infiltration

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10
Q

Things to ask in history

A
Age and nature of onset 
distribution 
medication history 
family history 
effective treatments 
QOL
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11
Q

Skin examination

A
distribution - symmetrical, extensor 
sharply demarcated plaques
erythematous 
papulosquamous
papules and pustules
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12
Q

Nails examination

A

onycholosis
pitting
oil spots

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13
Q

Name 8 types of psoriasis

A
erythematous 
palmo-plantar
chronic plaque 
guttate
scalp
nail 
flexural/inverse 
pustular
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14
Q

Guttate psoriasis - who is effected and triggers

A

children, young

viral/bacterial infection

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15
Q

Differential diagnoses for inverse psoriasis

A

dermatophye, candida or bacterial infection

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16
Q

Causes of pustular psoriasis

A

pregnancy, rapid stop steroids, hypocalcaemia, infection

17
Q

2 possible ways to diagnose psoriasis

A

clinical findings

biopsy if atypical

18
Q

3 differential diagnoses for psoriasis

A

seborrheic dermatitis
lichen planus
mycosis fungoides

19
Q

What is mycosis fungoides?

A

cutaneous lymphoma

20
Q

Treatment of psoriasis in GP

A
coal tar cream 
emollient 
soap substitute 
vitamin D3 analogues
salicylic acid 
topical steroids
21
Q

Treating psoriasis in secondary care

A
Crude coal tar 
dithranol 
UVB phototherapy 
retinoid 
immunosuppression 
biologic therapy
22
Q

Future therapies for psoriasis

A

targeted biologics
IL -17,20,22
kinase inhibitors

23
Q

Treatment of erythodermic psoriasis

A
IV/blood access 
emollient 
recognise 
admit 
fluid balance 
systemic or biologic treatment 
thick greasy emollient
24
Q

2 index to monitor progress

A

psoriasis area severity

dermatology life quality

25
Psoriasis area severity index factors
surface area plaque colour thickness scale
26
Dermatology life quality index factors
QOL in last week
27
psoriasis prognosis
3/4 year life reduction | linked to CVD, skin cancer, depression, suicide, smoking, alcohol