Psoriasis Flashcards
What is psoriasis?
Inflammatory skin disease; autoimmune; systemic; chronic relapsing.
What are the subtypes of psoriasis?
Chronic plaque, Pustular, Inverse, Guttate, Erythrodermic, Nail, Psoriatic Arthritis.
What are the risk factors for psoriasis?
Genetics, infections, drugs, UV light, stress, smoking, obesity.
What is the pathophysiology of psoriasis?
Trigger (trauma, stress, infection, drug) → Keratinocytes release LL37 → Activation of plasmacytoid dendritic cells → Maturation of myeloid dendritic cells → Th1 & Th7 maturation → Keratinocyte proliferation and dysfunctional differentiation.
What are some common triggers for psoriasis?
Trauma, stress, infection, drugs like lithium and chloroquine.
What are the aims of psoriasis treatment?
Increase skin hydration, remove scales, slow lesion proliferation, manage itching, and prevent complications.
What self-care advice is recommended for psoriasis patients?
Hydration, scale removal, and avoiding triggers like stress or smoking.
What is the prevalence of psoriasis?
Chronic relapsing inflammatory disorder, affecting 1-3% of the population, common in 20s or 50s.
How is psoriasis severity assessed?
Body Surface Area (BSA), Psoriasis Area and Severity Index (PASI), Dermatology Quality of Life Index (DLQI).
What are the aims of psoriasis treatment?
No cure; manage symptoms, achieve remission, and assess relative treatment effectiveness.
What is the pharmacist’s role in managing psoriasis?
Review adherence, provide lifestyle advice, counsel on treatments, and set realistic goals.
