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PHARM 154 > Psoriasis > Flashcards

Psoriasis Flashcards

1
Q

Define Psoriasis

A

white, silvery plaques

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2
Q

What is the cause of psoriasis?

A

fast over turn on skin cells creating patches

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3
Q

Explain what is the difference between mild, moderate and severe psoriasis

A

Mild < 3%
Moderate 3-10%
Severe >10%

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4
Q

What percentage of people with psoriasis will have some on the scalp?

A

50-80% will have some
it is hard to treat because of the level of the scalp

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5
Q

T/F Psoriasis will not be seen on the nails

A

False

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6
Q

What is the impact of psoriasis?

A

it can be physically disabling
there is also a social aspect

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7
Q

What are some things that worsen psoriasis?

A

cold weather
stress
trauma

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8
Q

What is something that helps with psoriasis?

A

sunlight

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9
Q

Explain the etiology of psoriasis

A

autoimmune
it has a genetic factor
it is about 12x normal rate of skin cell production

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10
Q

List the various treatments for psoriasis

A

emollients
keratolytics
tar
topical steroids
calcipotriol/ene
retinoids
antralin
phototherapy
biologic agents

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11
Q

What is psoriasis arthritis?

A

arthritis caused by inflammation (autoimmune)
and they have psoriasis

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12
Q

What amount of people with psoriasis will have psoriasis arthritis?

A

about 20%

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13
Q

What are some treatments for psoriasis arthritis?

A

Methotrexate
cyclosporine
TNF a blocker

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14
Q

MOA of methotrexate

A

immunosuppressant

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15
Q

MOA of cyclosporine

A

anti-rejection medication

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16
Q

MOA of TNF a Blocker

A

biologic agents

17
Q

MOA of Tar

A

anti-proliferative properties

18
Q

What are the caution with topical steroids?

A

long term AE

19
Q

MOA of calcipotriol

A

vit D analog

20
Q

MOA of retinoids for psoriasis

A

decreased cell proliferation

21
Q

MOA of phototherapy

A

narrow UVB/UVA
decreased cell proliferation

22
Q

How often is phototherapy needed?

A

2-3/wk

23
Q

What types of biologic agents used in psoriasis?

A

TNFa/ IL-23 antagonists

24
Q

What is the limit of biological agents?

A

they are very expensive

25
Q

What is used on the scalp for psoriasis?

A

Vit D or steroids

PHARM 154 (16 decks)

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