Protozoan Drugs : Parasitology

Question 1

Amoeba infection can be

Answer 1

Intraluminal
Extraluminal

Question 2

The luminal infection can cause

Answer 2

Amoebic colitis

Question 3

The extraluminal infection includes

Answer 3

Intestinal wall infestation, liver abscess and ameboma

Question 4

The liver abscess presents with smooth like mass on the abdomen but histologically presents as

Answer 4

Sclerosis in the outside
Chronic Inflammation on the inside

Question 5

For asymptomatic amoebiasis you give

Answer 5

Paramomycin
Diloxanide furoate
Iodoquinone

Question 6

What drug is used to treat mild to moderate intestinal/Intraluminal amoebiasis

Answer 6

Metronidazole
Paramomycin
Diloxanide furoate
Iodoquinole

Question 7

For severe intestinal amoebiasis

Answer 7

Metronidazole
Paramomycin
Diloxanide furoate
Iodoquinole

Question 8

For liver abscess amoebiasis what do you give to treat

Answer 8

Chloroquine
Metronidazole
Paramomycin
Diloxanide furoate
Iodoquinole

Question 9

For mixed infection of amoebiasis use

Answer 9

Emetine/hydroemetine
Chloroquine

Metronidazole
Paramomycin
Diloxanide furoate
Iodoquinole

Question 10

What form of leishmania between promastigote and mastigote is more susceptible to treatment

Answer 10

Promastigote

Question 11

What drugs are used to treat visceral leishmaniasis

Answer 11

Sodiumstibogluconate

Others:
Megcumin antinoate
Paramomycin
Amphotericin B

Question 12

What drugs are used in the treatment of cutaneous leishmaniasis

Answer 12

Sodiumstibogluconate
Megcumin antinoate

Amphotericin B
Pentamidine

Question 13

What is the drug of choice for AIDS patients with leishmaniasis

Answer 13

Miltafosine

Question 14

The species of black fly that transmit onchocerca is

Answer 14

Similium spp

Question 15

Treatment of onchocerca can be

Answer 15

Surgical
Pharmacological

Question 16

Effective drugs in the treatment of onchocerca volvulus

Answer 16

Ivermectin
Doxycycline
Moxidectin

Question 17

MOA of ivermectin

Answer 17

Causes flaccid paralysis in the worm by binding to and activating glutamate gated chloride channels irreversibly causing inhibitory post synaptic potentials

Question 18

Role of Doxycycline in onchocerca treatment

Answer 18

Antibiotics
Used in treating onchocerciasis with the aim of eradicating wolbachia bacteria which has symbiotic association with the worm

Question 19

Onset of action of trypanosoma infection

Answer 19

1-3weeks

Question 20

Trypanosomiasis is divided into two stages or phases

Answer 20

Hemolymphatic stage-first two weeks

Neurological stage/meninigoencephalitic stage -beyond 2 weeks

Question 21

Treatment of Stage I trypanosomis

Answer 21

Sara min
Pentamidine

Question 22

Treatment of stage two is with

Answer 22

Eflurnitine
Nifurtimox
Malarsoprol

Question 23

Drugs effective in the treatment of both stage I and stage II

Answer 23

Feximidazole
Malarsoprol

Question 24

What is used in early chargas disease

Answer 24

Mifurtimox
Benzimitdazole

Question 25

Drug of choice in toxoplasmosis treatment

Answer 25

Pyrimethamine Sulfadiaxine Spiramycin Clindamycin

Question 26

What is the MOA of pyrimethamine

Answer 26

Anti folate, folic acid antagonist

Question 27

Pneumocytosis is caused by

Answer 27

**Pneumocytosis jirovencii**

Question 28

What drug combination is used in treatment of Pneumocytosis

Answer 28

Trimethoprim-Sulfamethoxazole