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Pharmac > Malarial Chemotherapy > Flashcards

Malarial Chemotherapy Flashcards

1
Q

Example of a tissue schizonticide

A

Primaquine

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2
Q

Examples of a blood schizonticide

A

Chloroquine
Amodiaquine
Mefloquine
Quinine
Artemisinin
Piperaquine

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3
Q

What is the mechanism of action of Chloroquine

A

Prevents conversion of heme to hemozoin

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4
Q

Example of a gametocide

A

Primaquine
Quinine

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5
Q

Mech of Action of Artemisinin in malaria chemotherapy

A

Activated by intraparasitic heme iron which cleaves the artemisinin endoperoxide bridge leaving a lethal free radical to kill the parasite

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6
Q

Artemisinin based combination therapy for malarial chemotherapy

A

Artemether-Lumefantrine
Artesunate-Mefloquine
Artesunate-Amodiaquine
Artesunate-Sulfadoxine-pyrimethamine
Dihydroartemisinin-Piperaquine

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7
Q

Example of an 8amino quinolone

A

Primaquine

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8
Q

Example of a Bisquinoline

A

Piperaquine

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9
Q

Example of a 4amino quinolone

A

Choloroquine, Amodiaquine, Mefloquine

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Pharmac (27 decks)

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