protoozoa Flashcards
Protozoa in GI infectiosn
Giardia lamblia, entamoeba histolytica, cryptosporidiu
bloating, flatulence, foul smeeling, fatty diarrhea: often seen in campers / hikers
giardiasis (can also present w watery diarrhea)
bloating, flatulence, foul smeeling, fatty diarrhea: often seen in campers / hikers: think fat rich Ghiradelli chocolates for fatty stools of giardia
hwo is giardia transmitted
cysts in water
drinking contaminated water, food borne or person-person spread; fecal oral
giardia
how to diangose giardia
multinucleated trophozoites or cysts in stool, antigen detection
treatment of giardia
metronidazole
2 forms of giardia
trophozoite (pathogenic stage)
cyst (infective stage)
bilaterally symetric pear shaped organism w multiple flagella and 2 nuclei (owl-eye appearance);
trophoizoite
cysts are what shaped
oval; contain up to 4 nuclei
small bowel biopsy of giardia
villous atrophy, crypt hyperlasia
damage intestinal villi, leads to malabsorptin due to villous blunting and decrease levels of brush border enzymes
giardia
bloody diarrhea (dysentery), liver abscess (anchovy paste exudate), RUQ pain;
amebiasis
flask shaped ulcer
amebiasis
fluid filled cavity in liver in conjucntion w fever, chilld, RUQ pain
liver abscess in abesisas
transmission of entamoeba histolytica
cysts in water
non inflammmatory diarrhea: giardia ; this means
no fecal blood or leukocytes
Entamoeba Eats Erythrocytes
diagnosis of entabmoeab
enteamobea diagnosis
serology and/or trophozoites with englufed RBCs in cytoplasm or
cysts with up to 4 nuclei in stool
severe diarrhea in AIDS
cryptosporidium
cryptosporidium in immunocompentent hosts
mild disease (watery diarrhea)
oocysts in fresh water is transmission of
cryptosporidum
ooctysts on acid fast stian, antigen detection
cryptosporidium diagnosis
Protozoa Cns infections
toxoplasma gondii,
naegleria, foleri
trypanosoma brucei
classic triad in congenital toxoplasmosis
classic triad of chorioretinits
hydrocephalus,
intracranial calcifications
inflammation of choroids and retina that can have cotton-like white/yellow scars in retina
chorioretinits
multiple ring enhacning lesions on MRI is caused by
toxoplasma gondii
multiple ring enhancing lesions are what
brain abscesses: caused by reactivation in aids
transmission of toxoplasma gondii
cysts in meat (most common)
oocysts in cat feces
crosses placeneta 9pregnant women should avoid cats
toxoplasmic encepahtliits
headache, seizures
hydrocephalus: CNS inflammation enalrged by macrocephaly + enlargemnt of ventricles
Primary CNS lymphoma
large solitary lesions
(ring enhancing lesiosn)
but diffuse large cell NHL of B cell origin; assoc w EBV
neonates affected w toxoplasma gondiii
hepatomegaly, splenomegaly, rash, multiple nerve abnormalities: seizures, altered muscle tone, ocular movement defects
diagnosis of toxoplasma gondii
serology, biopsy (tachyzoite)
rapidly fatal meningoencephalitis: swimming in freshwater
naegleria fowleria