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corynlistnocardiaactino Flashcards

1
Q

Corynebacterium diphterhiae

ABCDEFG

A 
A: ADP ribosylation
B: B prophage
C: Corynebacterium
D: Diphteriae
E: Elongation Factor 2
G: granules
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2
Q

Gram + rod transmitted via resp droplets in se asia

A

corynebacterium diphterhiae

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3
Q

C. diphterhiae potent extoxin function

A

inhibits protein synthesis via ADP-ribosylation of EF-2

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4
Q

causes diphteria via exotoxin encoded by

A

B prophage

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5
Q

Pseudomembranous pharyngitis (grayish-white membrane w lymphadenopathy, myocarditis, and arrhytmias)

A

C. diphterhiae

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6
Q

Lab diagnosis of C diphterhiae

A

gram + rods w metachroomatic (blue and red) granules and + Elek test for toxin

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7
Q

what color are the granules in c diphterhiae

A

blue and red

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8
Q

Stain the metachromatic blue and red granules with

A

aniline dyes

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9
Q

how does toxoid vaccine prevent diphterhia

A

neutralizies IgG antibodies against binding component (B subunit) of diphterhia exotoxin)

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10
Q

when dealing with C. dificile what should you do

A

gown, nonsterile gloves

handwashing aw soap and water (alcohol based hand sanitizers) do NOT kill spores

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11
Q

on the cytsine-tellurite agar what color for C. diphteriae

A

black colonies

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12
Q

severe pharyngitis w exudates and cervical lymphadenopathy in a group of people with unknown vaccination statsu

A

resp diphteria infection; diphteria toxin: severe myocarditis and heart failure

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13
Q

function of A (active subunit ) of diphteriha AB exotoxin

A

transfer ribose residue from NAD to a histidine on EF-2; essential for peptide chain translocation on ribosome in process of translation

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14
Q

lysogenic bacteriophage called corynephage beta converts

A

nontoxigenic to toxigenic C. diphterhia due to infection

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15
Q

lysogenic bacteriophage inserts tox gene into genome: resulting in

A

expression of dipstheria AB toxin.

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16
Q

B subunit of diphtehria AB exotoxin binds to

A

heparin-binding epidermal growth factor receptor on cardiac + neural cells

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17
Q

intracellular pyrophosphate granules of c. diphterhiae visualized on microscopy after growing pathogen on

A

Loeffler medium - stain w mehtylene blue

rare in developed countries

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18
Q

narrow zone of beta hemolysis

A

listeria monocytogenes

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19
Q

faculattive intracellular rod; aerobic

A

listeria

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20
Q

acquired by ingestion of unpasteruized dairy products and cold deli meats, via transplacental transmission, or by vaginal transmission during birth

A

listeriaa

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21
Q

growsh well at refrigeration temps (4-10 C): cold enrichment

A

listeria

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22
Q

rocket tails via actin polymerization allow interacellular movement and cel to cell spread across cell membranes; thereby avoiding antibody

A

listeria

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23
Q

tumbilng motiliy at room temperature

A

listeria

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24
Q

what does listeria cause

A

amnionitis, septicemia, spontaneous abortion in pregnant women; granulomatosis infantiseptica; neonatal meningits; meningits in inmmunocomporsied pt’s ; midl , self limited gastroentertitis in healthy individuals

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25
listeria can be trasnimitted (pregnant)
transplacenntally or via vaginal contact during delivery causing neonatal menignits
26
in pregnant woemen, listeria causes greates risk in
3rd trimester; can cause preterm labor, neonatal sepsis
27
why is nocardia weakly acid fast
has mycolic acid in cell wall
28
where is nocardia found
in soil; disease from spore inhalation or traumatic inoculation into skin
29
where is actninomyces found
normal oral , reproductive, GI flora, colon
30
actinomyces is acid fast or no
not acid fast
31
causes pulmonary infections in immunocomporomised (can mimic TB but w - PPD)
nocardia
32
causes cutanoeus infectison after trauma in immunocompetent; can spread to CNS to cause brain abscesses ; seizures
nocardia
33
Treatment is SNAP
sulfonamdies: nocardia Actinomuces: penicillin
34
oral/facial abscesses that drain thorugh sinus tracts
actinomyces
35
forms yellow sulfur granules t
actinomyces
36
associated w dental caries/ extration and can fcause PID w IUDS
actinomyces
37
in the cervicofacial region; bacteria grow slowly and without regard to tissue planes ; indurated perimandibular mass that enlarges over time and evolves into multiple abscesses and draining sinus tracts
actinomyces
38
actinomyces israelii
gram + fungus like bacterium = thick peptidoglycan cell wall
39
K1 capsule
E. Coli
40
K1 capsule causes
pneumoniae, neonatal meningitis
41
LPS E. coli endotoxin cauess
septic shock
42
most common cause of UTI
E Coli
43
E. Coli fimbriae causes what
Cystitis and pyelonephritis (P-pili
44
E. coli adhesive proteins (virulence factor)
fimbriae
45
invasive; dysentery. manifestations similar to shigella
EIEc
46
traveller's diarrhea (watery)
ETEC
47
EIEC toxin and mechanism
microbe invades intestinal mucosa and causes necrosis and inflammation
48
ETEC toxin and mechanism
produces heat labile and heat stable entertoxins
49
which e. coli has no inflammation or invasion
ETEC
50
which e coli has no toxin produced
EPEC
51
diarrhea useally in children (Pediatrics)
EPEC
52
EPEC toxin and mechanism:
no toxin produced. adheres to apical surface; flattens villi, prevents absorption
53
O157:H7
EHEC
54
how is O157:H7 transmitted
undercooked meat, raw leafy vegetables
55
which bacteria grows on hypertonic saline and bile
entercoccus
56
which e coli does not ferment sorbitol like other e coli
EHEc
57
EHEC caues what
dysentery (toxin alone causes necrosis and inflammation)
58
EHEC has what type of toxin
Shiga like toxin
59
Shiga like toxin (verotoxin) does what
inactivates 60S ribosomal subunit in human cells: inhibition of protein syntehsis and eventual cell death
60
shiga like toxin causes
gastroenetritis (bloodY)
61
O antigen on E Coli means
this classifies Gram - bacteria; most extracellular comonent of LPS
62
heatl stabile enterotoxins increase
cGMP: causing watery diarrhea + electrolytile loss
63
NO production of glycuronidase like other E coli strands
EHEC
64
EHEC does not invade
intestinal mucosa
65
ETEC heat -labile toxin resembles
cholera toxin
66
heat labile entertoxin increases
cAMP in gut mucosal cells ; activates stimulatory Gs membrane G prtoein thereby actinvating adenylate cycalse
67
E coli is indole +. this means
can convert tryptophan to indole; distingushied from other enterobacter cloacea
68
normal flora of GI tract
e coli
69
Shiga like toxin is an A
AB toxin (active A subuint,5 binding sbunits)
70
flagellar (H antigen) : heat labile protein whichch is one compnent of serologic classification of
enterobateriaceae
71
thinck an E coli: stacked brick instestinal adhesion: organsims adhere to human jejunal, ileal, colonic mucosa in aggregative, stacked brick pattern; do not invade ; implicated in persistnet diarrhea in infants in developing countries.
EAEC
72
lobar pneumonia in alcholics
Klebsiella
73
intestinal flora that causes lobar pneumonia in diabetics when aspirated
klebbsiella
74
5A's of KlebsiellA
``` Aspiration pneimoniae Abscess in lungs and liver Alcoholics DiAbetics CurrAnt jelly sputum ```
75
Currant jelly sputum (blood/mucus)
it iis dark red. klebsellia
76
klebsiella abundant polysaccharide capsule causes what
very mucoid colonies
77
comma, S, shaped, motile , curved. oxidase +; grows in 42 C
C. jejuni
78
major cause of bloody diarrhea, esp in children. oxidase +
C. jejuni
79
C. jejuni trasnmission
fecal oral transmission thorugh person to person contact or via ingestion of undercooked contaminated poultry or meat, unpasteurized milk
80
infected animals w c jejuni
DOGS, cats, pigs risk factor
81
guillan barre syndrome
campylobacter jejuni
82
reactive arthritis
C. jejuni
83
AB exotoxin of C. Jejuni
increases cAMP in intestinal cells: decreased absorption and increase secretion of Na, Cl, H20
84
generates cross reacting antibodies to peripheral nerve myelin gangliosides
guillan barre syndrome
85
stool studies of c. jejuni
inflammation (leukocytes, ertyrhocytes); no ova or parasites
86
following ingestion, C. jejuni colonizes intestinal mucosa ; enters enterocytes within endocytic vacuoles and causes cytotoxic injury due to specific virulence factors
cytolethal distending toxin | lipoligosaccharide

Microbiology (13 decks)

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