Proteins Flashcards

1
Q

enzymes must break bonds and remove histone, revealing the _____ in DNA

A

promoter segment

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2
Q

nucleosomes repeat to make

A

chromatin

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3
Q

heterochromatin

A

“tight” genes off

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4
Q

Euchromatin

A

genes on

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5
Q

octamer consisting of two of each of

A

H2A, H2B, H3, H4 ( no H1)

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6
Q

Promotor regions are located upstream of the __ end

A

5’

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7
Q

2 types of transcription factors

A

gene-specific TF and general TF ( which are required to activate all genes)

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8
Q

what happened in CREM- mutant mice?

A

Spermatogenesis deficiency

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9
Q

exons vs introns

A

exons are the ones that get expressed

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10
Q

Epithelial cells attach to the

A

basal lamina ( cellular matrix layer that is secreted by the epithelial cells)

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11
Q

what characteristics to transporting epithelia have?

A

thicker, membrane mods, cell junctions and mitochondria

  • to regulate ion exchange selectively
  • absorption and secretion
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12
Q

exocrine vs endocrine?

A

exocrine glands–> release into external environment ( release into ducts) whereas endocrine is into the bloodstream

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13
Q

what is cystic fibrosis?

A

defective epithelial ion transport of chloride and sodium in exocrine tissues that leads to thick secretions in the lungs liver pancreas and reproductive tract and increased salt in sweat glands

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14
Q

genetic and molecular causes of CF?

A
  • faulty gene on chromosome 7
  • malfunction of the gene coding for the CF- transmembrane conductance regulator leads to defective cAMP-activated chloride and sodium channel that is on the surface of many cells
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15
Q

why does the mucus get dehydrated?

A

NaCl becomes trapped in the cell and pulls water in

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16
Q

patients with CF suffer from

A

multi systemic disease

17
Q

what are the chances of a child with both parents having CF to pass it to their children

A

1/4

18
Q

genetic screening says that there are over ____ mutations associated with CF

A

1100

19
Q

high levels of salt are in the _____ fluid

A

intracellular fluid

20
Q

Chloride and salt ions are trapped inside or out?

A

INSIDE so this ultimately leads to failure of water to leave the cell and then enhanced mucus secretion with no water to dilute it– thick and sticky