protein synthesis tetracycline Flashcards
1
Q
what does it bind to and what does it block
A
30s (via 16s rRNA and S4 or S18)
blocks binding of incoming aa-tRNA to A site
2
Q
what type of AB is it
A
bacteriostatic
3
Q
selectivity
A
inhibits both 80s and 70s
greater affinity in 70s as it is actively transported in prokaryotes
4
Q
side effects
A
interacts with divalent metals Ca2+ and Mg2+ so should not be taken with milk may stain developing teeth some skin photosensitivity may cause suprainfection
5
Q
what is suprainfection
A
allows other bateria that is not inhibited by tetracycline to be able to breed
