pharmacology of pain just drugs

Question 1

codeine what is it used for and what is it metabolised to

Answer 1

metabolised to morphine (20% of mrophines affect)
pain killer with no euphoria
limited substance abuse

Question 2

codeine what is it used in combo with

Answer 2

paracetamol = solpadol

Question 3

codeine how is it different to morphine

Answer 3

1 hydroxyl group has changed to methyl

Question 4

heroin facts

Answer 4

very lipid soluble so enters BBB
high potency by short lasting
metabolised to morphine

Question 5

heroin how is it different to morphine

Answer 5

both hydroxyl groups have been acetylated

Question 6

naloxone facts as a antagonist

Answer 6

acts on all receptors
little effect on its own
opioid poisoning
respiratory depression

Question 7

how is naloxone administered and for how long does it last

Answer 7

iv and short acting 2-4 h

Question 8

naltrexone facts as a anatagonist

Answer 8

acts on all opioid receptors
longer lasting —approx— 10h
alcohol dependence

Question 9

phenylpiperidine series fully synthetic

which 2 drugs and potency, duration

Answer 9

pethidine and fentanyl

less potent and shorter duration the morphine

Question 10

pethidine and fentanyl what are they used for

Answer 10

labour and post operative pain

Question 11

methadone series duration

what are they used for

Answer 11

longer duration of action 24-36h

maintainance therapy in heroin addition = decr dependence

Question 12

benzomorphan series drug used

features

Answer 12

pentazocine
mixed agonist/ antagonist (acts differently on different receptors)
used as analgesic
can cause dysphoria

Question 13

stereoisomers name both of them

their relative potencies

Answer 13

levorpham and dextrophan
l= 8x more potent (highly addictive)
D = no overlap with morphine