inhibitors of nucleic acid synthesis rifanficin Flashcards
1
Q
what type of AB is it
and what is it used against
A
bactericidal
against TB and leprosy, gram +ve
2
Q
what does it inhibit
A
rna pol
3
Q
what does it bind to
A
beta subunit of A2BB’(sigma)
4
Q
where does it act
A
on initiation
5
Q
what does it prevent
A
doesnt block formation of the first peptide bond but prevents further addition
after 3-4 phosphoester bonds have formed further elongation is blocked
6
Q
resistance
A
develops because of a single point mutation in beta subunit
should not be used in monotherapy
7
Q
what else does it induce
A
inducer of cytochrome p450
cyp2c9 and cyp3a4
induces synthesis of these thus changing other drug metabolisms
8
Q
what does elivated cytochrome p450 metabolise
A
warfarin
