inhibitors of nucleic acid synthesis, all the others Flashcards
1
Q
what drug is the inhibitor of DNA gyrase
A
quinolones
2
Q
what do quinolones inhibit
A
dna gyrase binding to A site
3
Q
what does quinolones affect
A
gram +ve and -ve
4
Q
what type of AB is quinolones
A
bacteriostatic at low conc
bactericidal at high conc
5
Q
what is quinolones used for
A
urinary tract infection
6
Q
what do fluoroquinolones do
A
they binds to DNA gyrase at A site
7
Q
what do fluoroquinolones affect
A
gram +ve and -VE
8
Q
what do fluoroquinolones inhibit
A
DNA gyrase and topo 4
9
Q
resistance to fluoroquinolones happen via
A
point mutation in the A subunit
eg ser 83 to trp
10
Q
coumermycin what does it inhibit
A
dna gyrase binding to beta subunit
11
Q
coumermycin is a
A
competative inhibitor of ATP binding
