protein synthesis erythromycin Flashcards
1
Q
what does it work against
what type of drug is it
what does it inhibit
A
gram +ve
bacteriostatic
inhibits translocation
2
Q
what is it used against
A
legionnaires disease
also for people who cant take penicillin
3
Q
selectivity
A
does not bind to 80s
high affinity for 70s at 10-8M
4
Q
what does it bind to
A
50s
on protein l15 and l16
5
Q
what does it do once bound
A
blocks the tunnel through which the peptide leaves as its being formed
peptidyl transferase centre
6
Q
resistance
A
maps in protein L4 and in rRNA
7
Q
side effects
A
inhibits cytochrome P450
