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Pharma Drugs > Protein Synthesis Inhibitors > Flashcards

Protein Synthesis Inhibitors Flashcards

1
Q

Aminoglycosides

A

binds to 30s
interferes w/ initiation complex / adds wrong AA / blocks proofreading

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2
Q

Aminoglycosides examples

A

gentamicin/tobramicin/amikacin (gta)

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3
Q

Aminoglycosides effective

A

aerobic g-ve

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4
Q

Aminoglycosides ineffective

A

g+ve / anaerobic g-ve

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5
Q

Aminoglycosides ADVERSE EFFECTS

A

nephrotoxicity , ototoxicity , 8th nerve damage , renal failure , tubular necrosis , exacerbates MG

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6
Q

Tetracyclines

A

bind to 30s / prevents tRNA binding to A site

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7
Q

Tetracyclines examples

A

doxycycline , minocycline , tigecycline.

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8
Q

Tetracyclines effective

A

G+ve B. / G-ve r (cholerae) , anaerobes , mycoplasma , spirochetes, chlamydia , rickettsia , protozoa

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9
Q

Tetracyclines ADVERSE

A

fungal superinfection , PC , damage of teeth & bones , ataxia , phototoxicity , worsens renal failure (not doxy)

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10
Q

Macrolides

A

binds to 50s / inhibits translocation / pregnancy & child safe

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11
Q

Macrolides examples

A

erythromycin , clarithromycin , azithromycin

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12
Q

Macrolides effective

A

G+ve b & c , G-ve r. & c , mycoplasma , spirochetes , chlamydia

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13
Q

Macrolides ADVERSE

A

NVD , Cramps , cholestatic jaundice (e)

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14
Q

Chloramphenicol

A

Binds to 50s / inhibits peptidyl transferase + mammalian mitochondrial protein synthesis

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15
Q

Chloramphenicol effective

A

MRSA , G+ve , G-ve , anaerobes , NM , HI , S. pneumoniae

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16
Q

Chloramphenicol treats

A

meningitis , typhoid fever , staph. brain abscess

17
Q

Chloramphenicol ADVERSE

A

idiosyncratic aplastic anemia , bone marrow suppression , Gray baby syndrome

18
Q

Clindamycin

A

binds to 50s , inhibits ribosomal translocation

19
Q

Clindamycin effective

A

MRSA , G+ve , anaerobes (BF)

20
Q

Clindamycin treats

A

lung abscess , bone & joint infections , mild acne

21
Q

Clindamycin ADVERSE

22
Q

Linezolid

A

binds to 23s of 50s / prevents 70s formation = no initiation

23
Q

Linezolid effective

A

MRSA , Vancomycin R. SA , VRE

24
Q

Linezolid ADVERSE

A

myelosuppression , NVD , altered taste

25
Q

Quinupristin / Dalfopristin

A

D: 23s of 50s / Q: 50s / prevents peptidyl transfer

26
Q

Quinupristin / Dalfopristin effective

A

MRSA , VRE

27
Q

Quinupristin / Dalfopristin ADVERSE

A

IV pain , phlebitis , myalgia

Pharma Drugs (11 decks)

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