Antimetabolites , fluoroquinolones , NSAIDS

Question 1

Antimetabolites

Answer 1

Sulfonamides
Trimethoprim
(Cotrimoxazole)

Question 2

Sulfonamides examples

Answer 2

sulfamethoxazole , sulfasalazine , silver sulfadiazine

Question 3

Sulfonamides MOA

Answer 3

Structural analogues of PABA , inhibit Dihydropteroate synthase = no FA = NO DNA/RNA

Question 4

Sulfonamides treat

Answer 4

burns (SS) , IBS (sulfasalazine) ,
prophylaxis & pneumocytosis jiroveci (cotrimoxazole)
Malaria/ Toxoplasmosis(w/ pyrimethamine)

Question 5

Sulfonamides ADVERSE

Answer 5

Teratogenic , hepatitis , NV , headache , depression , crystalluria , allergies , hives

Question 6

Trimethoprim MOA

Answer 6

inhibits dihydrofolate in bacteria + humans

Question 7

Trimethoprim treats

Answer 7

UTIs & LRTIs

Question 8

Trimethoprim ADVERSE

Answer 8

teratogenic (1st trimester) , blood dyscrasias , Hyperkalemia

Question 9

Fluoroquinolones example

Answer 9

Ciprofloxacin

Question 10

Ciprofloxacin MOA

Answer 10

inhibits topoisomerase II & IV = no DNA synthesis

Question 11

Ciprofloxacin effective

Answer 11

facultative , aerobic g-ve , g+ve , enterobacteriacae , NG , campylobacter , PA

Question 12

Ciprofloxacin ineffective

Answer 12

MRSA

Question 13

Ciprofloxacin treats

Answer 13

LRTIs , UTIs , Ext . Otitis , traveler’s diarrhea STDs , osteomyelitis , salmonella typhi carriers , prostatitis

Question 14

Ciprofloxacin ADVERSE

Answer 14

teratogenic , seizures , QT prolongation , tendon damage , nephrotoxicity , hepatotoxicity

Question 15

Ciprofloxacin CI

Answer 15

pregnant , children , Elderly + SSRI / macrolides users , w/ antacids / NSAIDS

Question 16

NSAIDS

Answer 16

Antiplatelets , analgesic , antipyretic , anti-inflammatory

Question 17

Non-selective NSAIDS

Answer 17

Aspirin , Naproxen , diclofenac, Indomethacin

Question 18

Preferential (COX 2 ) NSAIDS

Answer 18

Meloxicam

Question 19

Poor AI

Answer 19

Paracetamol

Question 20

Ibuprofen MOA

Answer 20

reversibly inhibits COX1 & 2

Question 21

Ibuprofen uses

Answer 21

AI , AP , Analgesic : R. arthritis , vasectomy , tooth damage , postpartum

Question 22

Ibuprofen ADVERSE

Answer 22

GI ulcers , bleeding , AKI , nephritis

Question 23

Paracetamol MOA

Answer 23

inhibits COX in CNS

Question 24

Paracetamol ADVERSE

Answer 24

hepatotoxicity , increases liver enzymes , hearing loss , erythema , hypersensitivity.

Question 25

Paracetamol CI

Answer 25

liver disease , w/ alcohol , hypersensitivity , kids > 2 yrs

Question 26

Celecoxib MOA

Answer 26

Sel. COX 2 inhibitor

Question 27

Celecoxib treats

Answer 27

R.arthritis , osteoarthritis

Question 28

Celecoxib ADVERSE

Answer 28

thrombosis , DVT , pulmonary embolism , Acute MI

Question 29

Aspirin MOA

Answer 29

IR. NSAID = suppressed TxA2 = inhibits PA

Question 30

Aspirin uses

Answer 30

low dose: antiplatelet / medium: analgesic + AP / high: AI

Question 31

Aspirin ADVERSE

Answer 31

Reye syndrome , dizziness , vertigo tinnitus , electrolyte imbalance