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Pharma Drugs > Antimetabolites , fluoroquinolones , NSAIDS > Flashcards

Antimetabolites , fluoroquinolones , NSAIDS Flashcards

1
Q

Antimetabolites

A

Sulfonamides
Trimethoprim
(Cotrimoxazole)

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2
Q

Sulfonamides examples

A

sulfamethoxazole , sulfasalazine , silver sulfadiazine

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3
Q

Sulfonamides MOA

A

Structural analogues of PABA , inhibit Dihydropteroate synthase = no FA = NO DNA/RNA

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4
Q

Sulfonamides treat

A

burns (SS) , IBS (sulfasalazine) ,
prophylaxis & pneumocytosis jiroveci (cotrimoxazole)
Malaria/ Toxoplasmosis(w/ pyrimethamine)

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5
Q

Sulfonamides ADVERSE

A

Teratogenic , hepatitis , NV , headache , depression , crystalluria , allergies , hives

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6
Q

Trimethoprim MOA

A

inhibits dihydrofolate in bacteria + humans

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7
Q

Trimethoprim treats

A

UTIs & LRTIs

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8
Q

Trimethoprim ADVERSE

A

teratogenic (1st trimester) , blood dyscrasias , Hyperkalemia

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9
Q

Fluoroquinolones example

A

Ciprofloxacin

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10
Q

Ciprofloxacin MOA

A

inhibits topoisomerase II & IV = no DNA synthesis

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11
Q

Ciprofloxacin effective

A

facultative , aerobic g-ve , g+ve , enterobacteriacae , NG , campylobacter , PA

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12
Q

Ciprofloxacin ineffective

A

MRSA

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13
Q

Ciprofloxacin treats

A

LRTIs , UTIs , Ext . Otitis , traveler’s diarrhea STDs , osteomyelitis , salmonella typhi carriers , prostatitis

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14
Q

Ciprofloxacin ADVERSE

A

teratogenic , seizures , QT prolongation , tendon damage , nephrotoxicity , hepatotoxicity

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15
Q

Ciprofloxacin CI

A

pregnant , children , Elderly + SSRI / macrolides users , w/ antacids / NSAIDS

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16
Q

NSAIDS

A

Antiplatelets , analgesic , antipyretic , anti-inflammatory

17
Q

Non-selective NSAIDS

A

Aspirin , Naproxen , diclofenac, Indomethacin

18
Q

Preferential (COX 2 ) NSAIDS

19
Q

Poor AI

A

Paracetamol

20
Q

Ibuprofen MOA

A

reversibly inhibits COX1 & 2

21
Q

Ibuprofen uses

A

AI , AP , Analgesic : R. arthritis , vasectomy , tooth damage , postpartum

22
Q

Ibuprofen ADVERSE

A

GI ulcers , bleeding , AKI , nephritis

23
Q

Paracetamol MOA

A

inhibits COX in CNS

24
Q

Paracetamol ADVERSE

A

hepatotoxicity , increases liver enzymes , hearing loss , erythema , hypersensitivity.

25
Q

Paracetamol CI

A

liver disease , w/ alcohol , hypersensitivity , kids > 2 yrs

26
Q

Celecoxib MOA

A

Sel. COX 2 inhibitor

27
Q

Celecoxib treats

A

R.arthritis , osteoarthritis

28
Q

Celecoxib ADVERSE

A

thrombosis , DVT , pulmonary embolism , Acute MI

29
Q

Aspirin MOA

A

IR. NSAID = suppressed TxA2 = inhibits PA

30
Q

Aspirin uses

A

low dose: antiplatelet / medium: analgesic + AP / high: AI

31
Q

Aspirin ADVERSE

A

Reye syndrome , dizziness , vertigo tinnitus , electrolyte imbalance

Pharma Drugs (11 decks)

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